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Carbene Complexes of Heme Proteins and Iron Porphyrin Models
The possible formation of carbene complexes of cytochromes P450 enzymes in various metabolisms of xenobiotics is first described. In view of these... -
Ferrocene–Peptide Bioconjugates
This chapter sketches an outline of ferrocene–peptide bioconjugates. A variety of ferrocene–peptide bioconjugates have been designed to induce... -
Catalytic Nickel–Iron–Sulfur Clusters: From Minerals to Enzymes
The geochemical theory of the origin of life proposes that primordial, pre-biotic reactions were carried out in a metal-sulfide-rich environment... -
Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and Other Ring-Fused 2-Pyridones
2-pyridones are important heterocycles with great applicability in medicinal chemistry and this core structure can be found in compounds with... -
Total Synthesis of Marine Macrolides
Recent progress (2002–2005) of total syntheses of bioactive marine macrolides, lasonolide A, zampanolide, dactylolide, and leucascandrolide A, was... -
Applications of Flexible Molecular Descriptors in the QSPR–QSAR Study of Heterocyclic Drugs
Various formulations of optimal descriptors introduced by different authors during the last 10 years are discussed for the special case of... -
QSAR and Molecular Modeling Studies of HIV Protease Inhibitors
Acquired immunodeficiency syndrome (AIDS) and its related disorders, caused by retrovirus human immunodeficiency virus (HIV) are a major health... -
Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles
This chapter aims to review recent developments in the synthesis of sulfur and nitrogen-containing heteroaromatic compounds under conditions that... -
Spectroscopic Study of the Structure of Zetekitoxin AB
Zetekitoxin (former name: atelopidtoxin) was reported by Mosher and colleagues in 1969 as a potent, water-soluble, guanidinium toxin found in... -
The Chemistry of 2-(1H)-Pyrazinones in Solution and on Solid Support
An overview on the microwave-enhanced synthesis and decoration of the 2(1H)-pyrazinone system is presented. Scaffold decoration using... -
In silico Studies on PPARγ Agonistic Heterocyclic Systems
Several heterocyclic derivatives like oxazolidinediones, thiazolidinediones, tetarazoles, phenoxazines, etc. are being developed for the treatment... -
Structural Information and Drug–Enzyme Interaction of the Non-Nucleoside Reverse Transcriptase Inhibitors Based on Computational Chemistry Approaches
Non-nucleoside reverse transcriptase inhibitors, such as nevirapine, TIBO, HEPT, and efavirenz, are very specific to HIV-1 reverse transcriptase... -
Manganese(III)-Based Peroxidation of Alkenes to Heterocycles
Synthesis of endoperoxides and hydroperoxides using tris(2,4-pentanedionato)manganese(III) or manganese(III) acetate is described. The reaction of... -
n-Body Decomposition Approach to the Calculation of Interaction Energies of Water Clusters
A new methodology is proposed in which large basis set MP2-level calculations can be extended to water clusters with as many as 50 monomers. The... -
Multiporphyrin ArraysAssembled Through Hydrogen Bonding
Although relatively weak in isolation, composite H-bonds can be used as an advantage for the assembly of relatively robust and well-defined arrays... -
Axial Coordination to Metalloporphyrins Leading to Multinuclear Assemblies
The use of axial coordination to metalloporphyrins is discussed on the basis of constructing multinuclear complexes. Starting with single... -
Intermolecular Interactions via Perturbation Theory: From Diatoms to Biomolecules
This article is devoted to the most recent, i.e. taking place within the last few years, theoretical developments in the field of intermolecular... -
Enzymatic Polymerization to Polysaccharides
Polysaccharides are formed by repeated glycosylations between a sugar donor and a sugar acceptor. This chapter reviews the in vitro synthesis of... -
PEGylation of Proteins as Tailored Chemistry for Optimized Bioconjugates
The high potential of peptides and proteins as therapeutic agents has not been fully exploited because of their common shortcomings: the only... -
Polymer Therapeutics for Cancer: Current Status and Future Challenges
Drug delivery systems for cancer therapeutics have revolutionized medicine. Delivery systems have improved the efficacy and reduced the toxicity of...