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Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-operative anxiety, depression,...
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METH exposure alters sperm DNA methylation in F0 mice and mPFC transcriptome in male F1 mice
RationaleMethamphetamine (METH) exposure has toxicity in sperm epigenetic phenotype and increases the risk for develo** addiction in their...
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HCN-Channel-Dependent Hyperexcitability of the Layer V Pyramidal Neurons in IL-mPFC Contributes to Fentanyl-Induced Hyperalgesia in Male Rats
Opioids are often first-line analgesics in pain therapy. However, prolonged use of opioids causes paradoxical pain, termed “opioid-induced...
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Chlorpromazine, an Inverse Agonist of D1R-Like, Differentially Targets Voltage-Gated Calcium Channel (CaV) Subtypes in mPFC Neurons
The dopamine receptor type 1 (D1R) and the dopamine receptor type 5 (D5R), which are often grouped as D1R-like due to their sequence and signaling...
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Minocycline Ameliorates Chronic Unpredictable Mild Stress-Induced Neuroinflammation and Abnormal mPFC-HIPP Oscillations in Mice
Stress-induced neuroinflammation is a hallmark of modern society and has been linked to various emotional disorders, including anxiety. However, how...
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Involvement of regulation of the excitation:inhibition functional balance in the mPFC in the antidepressant-anxiolytic effect of YL-IPA08, a novel TSPO ligand
TSPO, an 18 kDa translocator protein, has received increased attention due to its antidepressant-anxiolytic effects. The balance between...
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Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits
The ability of monkeys and rats to carry out spatial working memory tasks has been shown to depend on the persistent firing of pyramidal cells in the...
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To fight or not to fight: activation of the mPFC during decision to engage in aggressive behavior after ethanol consumption in a novel murine model
RationaleAlcohol consumption is a common antecedent of aggressive behavior. The effects of alcohol on the decision to engage in aggression in...
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The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction
Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and...
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Dopamine-induced astrocytic Ca2+ signaling in mPFC is mediated by MAO-B in young mice, but by dopamine receptors in adult mice
Dopamine (DA) plays a vital role in brain physiology and pathology such as learning and memory, motor control, neurological diseases, and psychiatric...
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Noradrenergic Regulation of the Medial Prefrontal Cortex Mediates Stress Co** in Postpartum Female Mice
The prevalence of depression in women increases during the postpartum period. We previously reported that subchronic exposure to social stress...
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Crocin Reverses Depression-Like Behavior in Parkinson Disease Mice via VTA-mPFC Pathway
Depression is a common non-motor symptom in patients with Parkinson’s disease (PD) and difficult to treat. Crocin is a natural multipotential...
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Cortico-cortical transfer of socially derived information gates emotion recognition
Emotion recognition and the resulting responses are important for survival and social functioning. However, how socially derived information is...
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Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
Nicotine addiction is a concern worldwide. Most mechanistic investigations are on nicotine substance dependence properties based on its...
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Acute Administration of HIV-1 Tat Protein Drives Glutamatergic Alterations in a Rodent Model of HIV-Associated Neurocognitive Disorders
HIV-1-associated neurocognitive disorders (HAND) are a major comorbidity of HIV-1 infection, marked by impairment of executive function varying in...
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Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex
Stressful circumstances are significant contributors to mental illnesses such as major depressive disorder. Anhedonia, defined as loss of the ability...
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Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its wake-like electroencephalogram. The neural activity...
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Sex-Related and Brain Regional Differences of URB597 Effects on Modulation of MAPK/PI3K Signaling in Chronically Stressed Rats
Gender differences exist in depression incidence and antidepressant efficacy. In addition to the neurotransmission theory of depression, inflammation...
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Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes
BackgroundMen and women are known to show differences in the incidence and clinical manifestations of mood and anxiety disorders. Many imaging...
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Distinct roles of the left and right prelimbic cortices in the modulation of ethanol consumption in male mice under acute and chronic social defeat stress
RationaleChronic stress exposure disrupts the medial prefrontal cortex’s (mPFC) ability to regulate impulses, leading to the loss of control over...
