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Transposable Element Structural Variants in Parkinson’s Disease: Focusing on Genoty** Alu Transposable Element Insertions with TypeTE
Genetic variation contributes significantly to Parkinson’s disease (PD)Parkinson’s disease (PD) risk, onset, and progression. However, most of the... -
Identification of transposable element families from pangenome polymorphisms
BackgroundTransposable Elements (TEs) are segments of DNA, typically a few hundred base pairs up to several tens of thousands bases long, that have...
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Transposable elements: McClintock’s legacy revisited
In 1983, Barbara McClintock was awarded the Nobel Prize in Physiology or Medicine for her discovery of transposable elements. This discovery was...
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Recurrent co-domestication of PIF/Harbinger transposable element proteins in insects
BackgroundTransposable elements (TEs) are selfish DNA sequences capable of moving and amplifying at the expense of host cells. Despite this, an...
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Distribution of Small RNAs Along Transposable Elements in Vitis vinifera During Somatic Embryogenesis
Metaviridae is a family of reverse-transcribing viruses, closely related to retroviruses; they exist within their host’s DNA as transposable... -
Towards targeting transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have...
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The Role of Transposable Elements in Long-Term Memory Formation
AbstractA number of experimental studies are described that challenge the significance of synaptic plasticity and prove the role of transposable...
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Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of mammalian genomic sequence. TEs are capable of making additional...
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Transposable Elements: Emerging Therapeutic Targets in Neurodegenerative Diseases
Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by...
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Meeting report: transposable elements at the crossroads of evolution, health and disease 2023
The conference “Transposable Elements at the Crossroads of Evolution, Health and Disease” was hosted by Keystone Symposia in Whistler, British...
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Migrators within migrators: exploring transposable element dynamics in the monarch butterfly, Danaus plexippus
BackgroundLepidoptera (butterflies and moths) are an important model system in ecology and evolution. A high-quality chromosomal genome assembly is...
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Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells
Transposable elements (TEs) are parasitic DNA sequences accounting for over half of the human genome. Tight control of the repression and activation...
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Reproducible evaluation of transposable element detectors with McClintock 2 guides accurate inference of Ty insertion patterns in yeast
BackgroundMany computational methods have been developed to detect non-reference transposable element (TE) insertions using short-read whole genome...
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Transposable elements as essential elements in the control of gene expression
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile elements, make up a significant portion of the genomes of...
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Orthoptera-TElib: a library of Orthoptera transposable elements for TE annotation
Transposable elements (TEs) are a major component of eukaryotic genomes and are present in almost all eukaryotic organisms. TEs are highly dynamic...
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CRISPR-TE: a web-based tool to generate single guide RNAs targeting transposable elements
BackgroundThe CRISPR/Cas systems have emerged as powerful tools in genome engineering. Recent studies highlighting the crucial role of transposable...
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A pangenome-guided manually curated library of transposable elements for Zymoseptoria tritici
ObjectivesHigh-quality species-specific transposable element (TE) libraries are required for studies to elucidate the evolutionary dynamics of TEs...
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The Dfam community resource of transposable element families, sequence models, and genome annotations
Dfam is an open access database of repetitive DNA families, sequence models, and genome annotations. The 3.0–3.3 releases of Dfam (
https://dfam.org ...