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Betaine Protects Mice from Cardiotoxicity Triggered by Sodium Arsenite Through Antioxidative and Anti-inflammatory Pathways
NaAsO 2 is known as a harmful pollutant all over the world, and many chronic heart diseases can be attributed to its prolonged exposure in NaAsO 2 -conta...
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Berberine alleviates sodium arsenite-induced renal and liver toxicity by regulating oxidative stress and inflammation in rats
BackgroundArsenic is ubiquitous in the environment, and long- or short-term exposure through water, food, and occupational sources can contribute to...
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Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats
Arsenic being a toxic metalloid ubiquitously persists in environment and causes several health complications including female reproductive anomalies....
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Increase of glycogen storage by sodium arsenite in rat cortical astrocytes through glycogen synthase activation and its association to toxicity
ObjectiveThe present study aimed primarily to evaluate the effect of sodium arsenite exposure on glucose metabolism includes glycogen accumulation on...
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Coenzyme Q10 protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice
BackgroundArsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on...
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Epigenetic effects of low-level sodium arsenite exposure on human liver HepaRG cells
Chronic exposure to inorganic arsenic is associated with a variety of adverse health effects, including lung, bladder, kidney, and liver cancer....
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Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring
Chronic exposure to inorganic arsenic (iAs) has been linked to diabetes in both humans and mice, but the role of iAs exposure prior to conception and...
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The role of PSMB5 in sodium arsenite–induced oxidative stress in L-02 cells
Endemic arsenism is widely distributed in the world, which can damage multiple organs, especially in skin and liver. The etiology is clear, but the...
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Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Chronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein that controls myriad cellular...
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Proteomic-miRNA Biomics Profile Reveals 2D Cultures of Human iPSC-Derived Neural Progenitor Cells More Sensitive than 3D Spheroid System Against the Experimental Exposure to Arsenic
The iPSC-derived 3D models are considered to be a connective link between 2D culture and in vivo studies. However, the sensitivity of such 3D models...
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Comparative cyto-genotoxicity and clastogenicity properties of traditional trypanocidal Afrormosia laxiflora and Lonchocarpus laxiflorus plants in Wistar rats
ObjectiveExpensiveness of trypanocides triggered the use of plants decoction as a therapeutic option after safety validation. We evaluated the...
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Integrated device for colorimetric detection of arsenite using polyethylene glycol capped gold nanoparticles—Lab-on-chip
ObjectiveThe importance of the detection of As (III) heavy metal has been increased due to its toxicity in the environment, which is ultimately...
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Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice
Arsenic poisoning in ground water is one of the most sensitive environmental pollutant causing serious pollution all over the world. Chronic arsenic...
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Chronic exposure to inorganic arsenic and fluoride induces redox imbalance, inhibits the transsulfuration pathway, and alters glutamate receptor expression in the brain, resulting in memory impairment in adult male mouse offspring
Exposure to toxic elements in drinking water, such as arsenic (As) and fluoride (F), starts at gestation and has been associated with memory and...
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Long-term spatial tracking of cells affected by environmental insults
BackgroundHarsh environments surrounding fetuses and children can induce cellular damage in the develo** brain, increasing the risk of intellectual...
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Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling
BackgroundArsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food...
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Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring
Chronic exposure to inorganic arsenic (iAs) has been linked to diabetic phenotypes in both humans and mice. However, diabetogenic effects of iAs...
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Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring
Exposure to fluoride (F) or arsenite (As) through contaminated drinking water has been associated with chronic nephrotoxicity in humans. Autophagy is...
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Regulation of rat HspB5/alphaB-Crystallin by microRNAs miR-101a-3p, miR-140-5p, miR-330-5p, and miR-376b-3p
HspB5/alphaB-crystallin is an ubiquitously expressed member of the small heat shock protein family which help cells to survive cellular stress...
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Chronic exposure to submicromolar arsenite promotes the migration of human esophageal Het1A cells induced by heparin-binding EGF-like growth factor
Chronic arsenic exposure causes cancers in multiple organs in humans. However, the mechanisms underlying arsenic-induced carcinogenesis remain...
