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Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19)
Lycopene is a group of phytochemicals found in nature, primarily in fruits and vegetables. Lycopene is thought to protect against a variety of...
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Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma
BackgroundCancer therapy targeting programmed death receptor-1 (PD-1 or CD279) or programmed death-ligand 1 (PD-L1 or CD274) gives hope to Tongue...
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Tomato (Lycopene and β-Carotene) and Cancer
Consuming fruits and vegetables regularly is able to decrease the risks of cancer, increase longevity and improve the quality of life. Among them,...
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The New 5'-UTR LcyE Allele Correlates with Increased Expression of the Lycopene-ε-Cyclase Gene Determining the Flow of the β-ε Branch of the Carotenoid Biosynthesis Pathway in Maize
AbstractThe color of the maize ( Zea mays L.) grain is determined by the content and composition of carotenoids, including provitamin A, which is a...
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Protective impact of lycopene on ethinylestradiol-induced cholestasis in rats
Protection against cholestasis and its consequences are considered an essential issue to improve the quality of a patient’s life and reduce the...
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Development of a Highly Water-Soluble Lycopene Cyclodextrin Ternary Formulation by the Integrated Experimental and Modeling Techniques
Lycopene, the aliphatic hydrocarbon carotenoid with abundant bioactivities, has instability, extremely poor water solubility, and low oral...
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The role of nitric oxide in anticonvulsant effects of lycopene supplementation on pentylenetetrazole-induced epileptic seizures in rats
Recent studies have shown that natural antioxidant compounds have positive effects on the nervous system. Lycopene, the red pigment in tomatoes, is...
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Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes
BackgroundInflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological...
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Lycopene and bone: an in vitro investigation and a pilot prospective clinical study
BackgroundThere are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent...
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Effect of individual and combined supplementation of phytoene, phytofluene, and lycopene against nicotine-induced pancreatic islet cell dysfunction
ObjectiveTo understand the capability of carotenoids phytoene, phytofluene, and lycopene supplementation individually and in combination to counter...
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Lycopene improves on basic hematological and immunological parameters in diabetes mellitus
ObjectiveDiabetes is associated with an upset of hematological and immunological parameters in humans, however information on the effects of Lycopene...
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Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2
PurposeStudies have controversially suggested that prostate cancer, the most common cancer among Western men, is less common among those with a high...
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Deciphering putative protein profile of a photomorphogenic high pigment mutant of Solanum lycopersicum (hp-1) by high-throughput LC–MS/MS analysis
The mutant hp-1 is a photomorphogenic high pigment tomato mutant. It has high commercial significance as a source of non-transgenic lycopene-rich...
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Antioxidants in Oral Cavity Disorders
Natural products can be used as therapeutic agents for several types of diseases, including those that affect the oral cavity. Among these products,...
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Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy
BackgroundPreviously suggested modifiable risk factors for prostate cancer could have resulted from detection bias because diagnosis requires a...
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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies
Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases....
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Consumption of lycopene-rich tomatoes improved glucose homeostasis in rats via an increase in leptin levels
The lycopene content of tomatoes is important because of its effects on vital physiological functions such as improvement of glucose tolerance and...
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Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a...
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Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells
BackgroundMonoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including...
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Role of Carotenoids in Preventing Oxidative Stress–Induced Cancer
Oxidative stress is the disproportion between the creation and balance of reactive oxygen species. Numerous recurrent ailments are described by high...