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Role of Carotenoids in Preventing Oxidative Stress–Induced Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Oxidative stress is the disproportion between the creation and balance of reactive oxygen species. Numerous recurrent ailments are described by high levels of inflammation and oxidative stress. Chemically, carotenoids are tetraterpenoids (C40 compounds), contain 8 isoprenoid residues, are mostly lipophilic in nature, and are synthesized by plants and few microorganisms; however, animals must take them through diet or food supplements. Carotenoids are classified into two basic groups – carotenes and xanthophylls. Lycopene, α-carotene and beta-carotene, comes under carotenes having hydrocarbon chain, while xanthophylls including lutein, zeaxanthin, beta-cryptoxanthin, and astaxanthin are oxidized derivatives of carotenes. Additionally, in the human body vitamin A (provitamin A carotenoids) is derived from dietary carotenoids.

There is actually a huge number of exploration considers that have researched the part of carotenoids in human health, beginning in the 1800s. A large number of studies have shown that carotenoids are related to antioxidant properties, immune modulators, reduced risk of various types of cancers, coronary artery diseases, and some eye disorders. This chapter discusses the types, sources, synthesis, uses, and protective efficacy of various types of carotenoids. Moreover, this chapter highlights the antioxidant properties of carotenoids, reflecting a wide range of key functional roles in biology.

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Authors and Affiliations

  1. Division of Biochemistry, Malabar Cancer Centre, Kannur, Kerala, India

    Edakkadath Raghavan Sindhu

  2. Department of Biochemistry, Co operative Institute of Health Sciences, Kannur, Kerala, India

    Antholi Keloth Kavya

  3. Royal Dental College, Palakkad District, Kerala, India

    Ponnamparambil Purushothaman Binitha

Authors
  1. Edakkadath Raghavan Sindhu
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  2. Antholi Keloth Kavya
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  3. Ponnamparambil Purushothaman Binitha
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Editor information

Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Sindhu, E.R., Kavya, A.K., Binitha, P.P. (2022). Role of Carotenoids in Preventing Oxidative Stress–Induced Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_27

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