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Macrolides as Immunomodulatory Agents
For over 50 years, clinicians have known that macrolide antibiotics have effects on inflammation and the immune system that are not related to their...
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Dose-related immunomodulatory effects of recombinant TRAIL in the tumor immune microenvironment
BackgroundIn addition to specifically inducing tumor cell apoptosis, recombinant tumor necrosis factor (TNF)-related apoptosis-inducing ligand...
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The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
ObjectiveThe study aimed to explore the immunomodulatory effects of clinically relevant concentrations of metformin on macrophages during sepsis,...
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Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients
BackgroundEpirubicin/cyclophosphamide (EC) and docetaxel (D) are commonly used in a sequential regimen in the neoadjuvant treatment of early,...
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ACKR3 Antagonism Enhances the Repair of Demyelinated Lesions Through Both Immunomodulatory and Remyelinating Effects
Addressing inflammation, demyelination, and associated neurodegeneration in inflammatory demyelinating diseases like multiple sclerosis (MS) remains...
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A review on immunomodulatory effects of BPA analogues
Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. Due to...
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Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by...
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Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as negative regulators of...
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Evaluation of immunomodulatory effects of co-culture or supernatant of dexamethasone or IFN-γ-treated adipose-derived mesenchymal stem cells on spleen mononuclear cells
Although mesenchymal stem cells (MSCs) have exhibited promising immunomodulatory potential in preclinical studies, clinical studies have revealed...
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Synergistic Potential of Antigen-Specific Vaccines and Immunomodulatory Agents for Lung Cancer Treatment
Lung cancer is one of the most fatal cancer types, with a mortality rate of 87% in a single year. Due to the immune evasion strategies of tumor...
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Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications
Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and play essential roles in tissue regeneration and homeostasis. MSCs can be...
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Antioxidant/Pro-oxidant, Anti-inflammatory, and Immunomodulatory Effects of Thymoquinone in Cancer Prevention and Treatment
Cancer, considered as the second leading cause of death after myocardial infarction, is a major health problem around the world. Since conventional...
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Antioxidant/Pro-oxidant, Anti-inflammatory, and Immunomodulatory Effects of Thymoquinone in Cancer Prevention and Treatment
Cancer, considered as the second leading cause of death after myocardial infarction, is a major health problem around the world. Since conventional...
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Therapeutic and immunomodulatory potentials of mesenchymal stromal/stem cells and immune checkpoints related molecules
Mesenchymal stromal/stem cells (MSCs) are used in many studies due to their therapeutic potential, including their differentiative ability and...
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Low-Intensity Pulsed Ultrasound: A Physical Stimulus with Immunomodulatory and Anti-inflammatory Potential
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind...
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Macrolides as Immunomodulatory Agents
Diffuse panbronchiolitis (DPB) is a disease characterized by diffuse bilateral centrilobular lesions consisting of peribronchial infiltration of...
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PpSP32, the Phlebotomus papatasi immunodominant salivary protein, exerts immunomodulatory effects on human monocytes, macrophages, and lymphocytes
BackgroundThe saliva of sand flies, vectors of Leishmania parasites, contains several components that exert pharmacological activity facilitating...
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Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4+ T cells in patients with primary Sjögren's syndrome
BackgroundPrimary Sjögren's syndrome (pSS) is an autoimmune disease that leads to the destruction of exocrine glands and multisystem lesions....
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Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts
Aframomum melegueta K Schum ( A. melegueta ), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory...
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Immunomodulatory effects of β-defensin 2 on macrophages induced immuno-upregulation and their antitumor function in breast cancer
BackgroundMacrophages are mononuclear CD34 + antigen-presenting cells of defense mechanism and play dual roles in tumor burden. The immunomodulatory...
