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Antioxidant/Pro-oxidant, Anti-inflammatory, and Immunomodulatory Effects of Thymoquinone in Cancer Prevention and Treatment

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Cancer, considered as the second leading cause of death after myocardial infarction, is a major health problem around the world. Since conventional methods such as chemotherapy and radiotherapy are often insufficient in cancer treatment, studies for alternative treatment methods are pursued. Researchers have been investigating the low doses of high selectivity plant-based active ingredients to kill cancer cells. In recent years, medicinal plants and their active ingredients have been used as an alternative therapy method in many diseases such as cancer, and their positive effects have been shown. Thymoquinone (TQ), an active ingredient of Nigella sativa (N. sativa), is used in both the prevention and treatment of various types of cancer due to its antioxidant/pro-oxidant, anti-inflammatory, and immunomodulatory properties.

Methods: In this context, in the light of the literature, both prevention and treatment of cancer and antioxidant/pro-oxidant, anti-inflammatory, and immunomodulatory activities of TQ will be evaluated.

Results: In this section, we provide a review on the antioxidant/pro-oxidant, anti-inflammatory, and immunomodulatory role of TQ in cancer prevention and treatment based on in vitro and in vivo studies.

Conclusion: TQ has an important role in the prevention and treatment of cancer with its antioxidant/pro-oxidant, anti-inflammatory, and immunomodulatory effects; however, clinical data is not sufficient. To explore the exact benefits of TQ in cancer management, further clinical studies are required.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Bezmialem Vakif University School of Medicine, Istanbul, Turkey

    Abdurrahim Kocyigit

  2. Bezmialem Vakif University Traditional and Complementary Medicine Advanced Research Applications and Research Center, Istanbul, Turkey

    Abdurrahim Kocyigit

  3. Department of Medical Biochemistry, University of Health Sciences Turkey, Hamidiye School of Medicine, Istanbul, Turkey

    Eray Metin Guler

  4. Department of Medical Biochemistry, University of Health Sciences Turkey, Haydarpasa Numune Health Application and Research Center, Istanbul, Turkey

    Eray Metin Guler

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  1. Abdurrahim Kocyigit
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  2. Eray Metin Guler
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Correspondence to Abdurrahim Kocyigit .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Department of Internal Medicine, General Hospital Minamiseiko Hospital, Nagoya, Japan

    Takehiko Takayanagi

  2. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Prakash Radhakrishnan

  3. Department of Nutrition and Dietetics, Faculty of Health Sciences, Bezmialem Vakif University, Istanbul, Turkey

    Ayse Günes-Bayir

  4. Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, Illinois, USA

    Gnanasekar Munirathinam

  5. Dean, Research, Central University of Punjab, Bathinda, Punjab, India

    Anjana Munsi

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Kocyigit, A., Guler, E.M. (2022). Antioxidant/Pro-oxidant, Anti-inflammatory, and Immunomodulatory Effects of Thymoquinone in Cancer Prevention and Treatment. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-5422-0_193

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