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Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation
Sleep is critical for maintaining overall health. Insufficient sleep duration and poor sleep quality are associated with various physical and mental...
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BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells
BackgroundTriple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and...
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Long non-coding RNA NEAT1 facilitates the growth, migration, and invasion of ovarian cancer cells via the let-7 g/MEST/ATGL axis
Background/AimGrowing evidence indicates a significant role of long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in ovarian...
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Assessment of lipolysis biomarkers in adipose tissue of patients with gastrointestinal cancer
BackgroundAdipose tissue metabolism may be impaired in patients with cancer. In particular, increased lipolysis was described in cancer-promoting...
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Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity
The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis (MS)....
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PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle
The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we...
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Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration
Hematopoietic stem cells (HSCs) regenerate after myeloablation, a procedure that adversely disrupts the bone marrow and drives leptin...
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Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury
Lipid droplets (LDs) were reported to play an important role in the modulation of inflammation and various cellular processes among multiple cell...
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Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet
Natural bioactive compounds have attracted a great deal of attention since some of them can act as thermogenesis activators. In recent years, special...
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Pigment epithelium-derived factor, an anti-VEGF factor, delays ovarian cancer progression by alleviating polarization of tumor-associated macrophages
Ovarian cancer (OC) is one of the most dangerous gynecological malignancies with no effective treatment so far. Pigment epithelium-derived factor...
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FUS Mutation Causes Disordered Lipid Metabolism in Skeletal Muscle Associated with ALS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by dysfunction of the upper and lower motor neurons...
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ROS-dependent HIF1α activation under forced lipid catabolism entails glycolysis and mitophagy as mediators of higher proliferation rate in cervical cancer cells
BackgroundIn the last decades, the concept of metabolic rewiring as a cancer hallmark has been expanded beyond the “Warburg effect” and the...
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Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
Acquisition of a lipid-laden phenotype by immune cells has been defined in infectious diseases and atherosclerosis but remains largely...
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Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Metabolic syndrome and obesity have detrimental effects on the metabolic function of the skeletal muscle. Mounting evidence indicates that patients...
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CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis
Comparative gene identification-58 (CGI-58), also known as α/β-hydrolase domain-containing 5 (ABHD5), is a member of a large family of proteins...
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The role of GPR81–cAMP–PKA pathway in endurance training-induced intramuscular triglyceride accumulation and mitochondrial content changes in rats
The athlete's paradox phenomenon involves the accumulation of intramuscular triglycerides (IMTG) in both insulin-resistant and insulin-sensitive...
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Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1α signaling pathway in 3T3-L1 preadipocytes
Heat stress (HS) results in health problems in animals. This study was conducted to investigate the effect and the underlying mechanism of HS on the...
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Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions
BackgroundExcessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte...
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Adipose Tissue Lipid Metabolism During Exercise
Adipose tissue-derived fatty acids are the primary source of energy during low-intensity exercise. Although the relative contribution of fat to...
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Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells
Zika virus (ZIKV) infection is a global public health concern linked to adult neurological disorders and congenital diseases in newborns. Host lipid...
