Search
Search Results
-
Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
The organosulfur compound sulforaphane (SFN; C 6 H 11 NOS 2 ) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and...
-
Neuroprotection of dexmedetomidine against propofol-induced neuroapoptosis partly mediated by PI3K/Akt pathway in hippocampal neurons of fetal rat
The aim was to investigate how the PI3K/Akt pathway is involved in the protection of dexmedetomidine against propofol. The hippocampal neurons from...
-
Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury
Spinal cord injury (SCI), which is much in the public eye, is still a refractory disease compromising the well-being of both patients and society. In...
-
Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of...
-
The effects of dietary choline
Food intake can influence neuronal functions through different modulators expressed in the brain. The present review is a report through relevant...
-
Duplicate preconditioning with sevoflurane in vitro improves neuroprotection in rat brain via activating the extracellular signal-regulated protein kinase
ObjectiveSevoflurane preconditioning has been demonstrated to reduce cerebral ischemia-reperfusion (IR) injury, but the underlying mechanisms have...
-
Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons
Most axons in the vertebral central nervous system are myelinated by oligodendrocytes. Myelin protects and insulates neuronal processes, enabling the...
-
Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia
ObjectiveCisplatin exerts its cytotoxic effect through distinct DNA lesions, leading to peripheral neuropathy. The risk of sensory neuropathy is a...
-
Regulation of β cleavage of amyloid precursor protein
Alzheimer’s disease ranks the first cause for senile dementia. The amyloid cascade is proposed to contribute to the pathogenesis of this disease. In...
-
Regulatory effects of insulin-like growth factor-1 on the expression of sensory neuropeptide mRNAs in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate
ObjectiveTo determine the effects of insulin-like growth factor-1 (IGF-1) on the expression of preprotachykinin (PPT) mRNA encoding substance P (SP)...
-
Treatment strategies for Parkinson’s disease
Parkinson’s disease (PD) is caused by progressive degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNpc), resulting in...
-
Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model
ObjectiveTo study the neuroprotective mechanism of minocycline against vascular cognitive impairment after cerebral ischemia.
Methods ... -
Dietary restriction and brain health
The benefits of dietary restriction (DR) on health and aging prevention have been well recognized. Recent studies suggest that DR may enhance brain...
-
Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer’s disease
Neuroinflammation has always been of concern in the pathogenesis of Alzheimer’s disease (AD). As a major inflammatory mediator, prostaglandin E 2 (PGE 2 )...
-
NMDA receptor antagonist MK-801 reduces neuronal damage and preserves learning and memory in a rat model of traumatic brain injury
ObjectiveNMDA receptor channel plays an important role in the pathophysiological process of traumatic brain injury (TBI). The present study aims to...
-
Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status
ObjectiveThe neuroprotective roles of cyclooxygenase (COX) and lipooxygenase (LOX) inhibitors have been well documented. Quinolinic acid (QA) is a...
-
Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure
ObjectiveExcessive aluminum (Al) exposure impairs neurocognitive function in humans and animals. Epidemiologic studies have shown a potential linkage...
-
The mechanisms of brain ischemic insult and potential protective interventions
The mechanisms of brain ischemic insult include glutamate excitoxicity, calcium toxicity, free radicals, nitric oxide, inflammatory reactions, as...
-
Relationship between transmembrane signal transduction pathway and DNA repair and the mechanism after global cerebral ischemia-reperfusion in rats
ObjectiveTo investigate the protein levels of phospho-ERK and phospho-APE/Ref-1 in hippocampal neurons after global cerebral ischemia reperfusion in...
-
Protective effects of edaravone against cobalt chloride-induced apoptosis in PC12 cells
ObjectiveTo investigate the neuroprotective effects of edaravone (Eda) on cobalt chloride (CoCl 2 )-induced oxidative stress and apoptosis in cultured...