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Showing 161-180 of 1,227 results

  1. Comparative deletion map** at 1p31.3-p32.2 implies NFIA responsible for intellectual disability coupled with macrocephaly and the presence of several other genes for syndromic intellectual disability

    Background

    While chromosome 1 is the largest chromosome in the human genome, less than two dozen cases of interstitial microdeletions in the short arm...

    Jonathan D. J. Labonne, Yi** Shen, ... Hyung-Goo Kim in Molecular Cytogenetics
    Article Open access 17 March 2016

  2. Targeting Nonsense Mutations in Diseases with Translational Read-Through-Inducing Drugs (TRIDs)

    In recent years, remarkable advances in the ability to diagnose genetic disorders have been made. The identification of disease-causing genes allows...

    Kerstin Nagel-Wolfrum, Fabian Möller, ... Uwe Wolfrum in BioDrugs
    Article 17 February 2016

  3. Current Perspective of Stem Cell Therapy in Neurodegenerative and Metabolic Diseases

    Neurodegenerative diseases have been an unsolved riddle for quite a while; to date, there are no proper and effective curative treatments and only...

    Ajay Kumar, Karthikeyan Narayanan, ... Balázs Gulyás in Molecular Neurobiology
    Article 04 November 2016

  4. Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques

    Immune pressure exerted by MHC class I-restricted cytotoxic T cells drives the development of viral escape mutations, thereby regulating HIV disease...

    Sarah E. Beck, Kathleen M. Kelly, ... Joseph L. Mankowski in Journal of NeuroVirology
    Article 12 February 2015

  5. Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease

    Sandhoff disease (SD) is caused by deficiency of N-acetyl-β-hexosaminidase (Hex) resulting in pathological accumulation of GM2 ganglioside in...

    V J McCurdy, H E Rockwell, ... D R Martin in Gene Therapy
    Article 04 December 2014

  6. Cellular Applications of Semiconductor Quantum Dots at the U.S. Naval Research Laboratory: 2006–2016

    Since they were first described over two decades ago, interest in interfacing highly fluorescent semiconductor nanocrystals, or quantum dots, with...
    Clare E. Rowland, Kimihiro Susumu, ... James B. Delehanty in Reviews in Fluorescence 2016
    Chapter 2017

  7. IL-27: Structure, Regulation, and Variability

    Interleukin 27 (IL-27) is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence...
    Marek Jankowski, Tomasz Wandtke in Interleukin-27: Biological Properties and Clinical Application
    Chapter 2016

  8. GABA (γ-Aminobutyric Acid)

    Vlainic Josipa, Jazvinscak Jembrek Maja in Encyclopedia of Signaling Molecules
    Living reference work entry 2016

  9. Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases

    The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a multifunctional single transmembrane glycoprotein. Recent studies...

    Y. Wang, R.G. MacDonald, ... S. Kar in Molecular Neurobiology
    Article 19 March 2016

  11. Cell Therapy for Pediatric Disorders of Glia

    The childhood disorders of glia comprise a group of diseases that include the pediatric leukodystrophies and lysosomal storage disorders, cerebral...
    M. Joana Osorio, Steven A. Goldman in Translational Neuroscience
    Chapter 2016

  12. DC-SIGN in Infection and Immunity

    Dendritic cells (DCs) play a central role in the immune system by patrolling peripheral tissues to sample antigens to induce antigen-specific...
    Joris K. Sprokholt, Ronald J. Overmars, Teunis B. H. Geijtenbeek in C-Type Lectin Receptors in Immunity
    Chapter 2016

  13. Stem Cell Therapy for GVHD

    Graft-versus-host disease (GVHD) is a major complication associated with morbidity and mortality following allogeneic hematopoietic stem cell...
    Nayoun Kim, Seok-Goo Cho in Stem Cells: Basics and Clinical Translation
    Chapter 2015

  14. Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

    Background

    The neuronal ceroid lipofuscinoses (NCLs; or Batten disease) are fatal inherited human neurodegenerative diseases affecting an estimated...

    Graham W Kay, David N Palmer in Journal of Neuroinflammation
    Article Open access 30 July 2013

  15. Interleukin 27

    Marcel Batten, Dipti Vijayan in Encyclopedia of Inflammatory Diseases
    Living reference work entry 2014

  16. Current Advances in Genome Detection of Peste des Petits Ruminants Virus

    Molecular techniques have given various opportunities to detect the genome of peste des petits ruminants virus (PPRV) at high resolutions, and these...
    Emmanuel Couacy-Hymann in Peste des Petits Ruminants Virus
    Chapter 2015

  17. Transplantation of Stem Cells to Treat Patients with Multiple Sclerosis

    Multiple sclerosis (MS) is an acquired inflammatory and neurodegenerative immune-mediated disorder of the central nervous system (CNS), characterized...
    Cecilia Laterza, Gianvito Martino in Stem Cells and Cancer Stem Cells, Volume 13
    Chapter 2015

  18. Comparative Efficacy of an Imidacloprid/Flumethrin Collar (Seresto®) and an Oral Fluralaner Chewable Tablet (Bravecto®) against Tick (Dermacentor variabilis and Amblyomma americanum) Infestations on Dogs: a Randomised Controlled Trial

    This controlled laboratory study demonstrated the residual speed of efficacy of an imidacloprid/flumethrin collar (Seresto ® , Bayer) for the control...

    Cameon M. Ohmes, Joe Hostetler, ... William R. Everett in Parasitology Research
    Article Open access 09 July 2015

  20. Genotype–phenotype correlation and mutation spectrum in a large cohort of patients with inherited retinal dystrophy revealed by next-generation sequencing

    Purpose:

    Inherited retinal dystrophy (IRD) is a leading cause of blindness worldwide. Because of extreme genetic heterogeneity, the etiology and...

    **u-Feng Huang, Fang Huang, ... Zi-Bing ** in Genetics in Medicine
    Article Open access 06 November 2014
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