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Transplantation of Stem Cells to Treat Patients with Multiple Sclerosis

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Stem Cells and Cancer Stem Cells, Volume 13

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 13))

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Abstract

Multiple sclerosis (MS) is an acquired inflammatory and neurodegenerative immune-mediated disorder of the central nervous system (CNS), characterized by inflammation, demyelination and axonal degeneration. In the most recent years, pre-clinical data have been accumulated in experimental models of demyelination – mimicking the pathogenic processes occurring in human MS – suggesting that therapies based on the transplantation of stem/precursor cells from various sources (i.e. neural stem/precursor cells, oligodendrocyte precursor cells, mesenchymal stem cells) can contribute to prevent or repair the CNS damage via different mechanisms. However, there are still unsolved issues concerning how to repair chronic MS lesions and whether transplanted cells can overcome the inhibitory microenvironment that restrain the endogenous repair. In order to translate preclinical research from bench-to-bedside, it is still mandatory to assess the optimal cell source, the timing and route of cell delivery, the therapeutic windows and the best cohort of patient potentially responsive for stem cell-based treatments.

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Authors and Affiliations

  1. Division of Neuroscience, Institute of Experimental Neurology-DIBIT 2, San Raffaele Scientific Institute, Milan, Italy

    Cecilia Laterza & Gianvito Martino

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  1. Cecilia Laterza
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  2. Gianvito Martino
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Correspondence to Gianvito Martino .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Laterza, C., Martino, G. (2015). Transplantation of Stem Cells to Treat Patients with Multiple Sclerosis. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 13. Stem Cells and Cancer Stem Cells, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7233-4_4

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