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Cell Therapy for Pediatric Disorders of Glia

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Translational Neuroscience

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Abstract

The childhood disorders of glia comprise a group of diseases that include the pediatric leukodystrophies and lysosomal storage disorders, cerebral palsies and perinatal hypoxic ischemic encephalopathies, and selected neurodevelopmental disorders of glial origin. Essentially, all of these disorders are associated with oligodendrocytic failure and dysmyelination, whether congenital or progressive, and most are attended by astrocytic dysfunction as well. In light of the wide range of disorders to which glial dysfunction and demyelination may contribute, and the relative homogeneity of glial progenitor cells (GPCs) and their derivatives, the glial disorders may be uniquely attractive targets for cell-based therapeutic strategies, and the pediatric disorders especially so. As a result, GPCs, which can distribute throughout the neuraxis and give rise to new astrocytes and myelinogenic oligodendrocytes, have become of great interest as candidates for the therapeutic restoration of normal glial architecture and function, as well as new myelin, to the pediatric brain.

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Acknowledgements

Dr. Goldman is supported by NINDS, NIMH, the National Multiple Sclerosis Society, the CHDI Foundation, New York Stem Cell Science (NYSTEM), the Mathers Charitable Foundation, the Adelson Medical Research Foundation, and the Novo Nordisk Foundation. We thank Drs. Martha Windrem and Abdellatif Benraiss for their help with figure presentation.

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Authors and Affiliations

  1. Center for Basic and Translational Neuroscience, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, 2200, Denmark

    M. Joana Osorio MD & Steven A. Goldman MD, PhD

  2. Department of Neurology, Center for Translational Neuromedicine, URMC-Strong Memorial Hospital, University of Rochester Medical Center, 601 Elmwood Avenue, 645, Rochester, NY, 14642, USA

    Steven A. Goldman MD, PhD

Authors
  1. M. Joana Osorio MD
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  2. Steven A. Goldman MD, PhD
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Correspondence to M. Joana Osorio MD or Steven A. Goldman MD, PhD .

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  1. UnivofCA-SanDiego,VeteransAdmintnMedCntr, Translational Neuroscience Institute, La Jolla, California, USA

    Mark H. Tuszynski

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Joana Osorio, M., Goldman, S.A. (2016). Cell Therapy for Pediatric Disorders of Glia. In: Tuszynski, M. (eds) Translational Neuroscience. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7654-3_15

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