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Peripheral BDNF Regulates Somatosensory–Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain
Brachial plexus avulsion (BPA) is a combined injury involving the central and peripheral nervous systems. Patients with BPA often experience severe...
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Taurine Promotes Differentiation and Maturation of Neural Stem/Progenitor Cells from the Subventricular Zone via Activation of GABAA Receptors
Neurogenesis, the formation of new neurons in the brain, occurs throughout the lifespan in the subgranular zone of the dentate gyrus and...
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Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain
BackgroundLong-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior...
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Peroxisome proliferator-activated receptor-γ doesn’t modify altered electrophysiological properties of the CA1 pyramidal neurons in a rat model of hepatic cirrhosis
Regarding the low quality of life due to the cognitive complications in the patients with hepatic cirrhosis (HC), the goal of this study was to...
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Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway
The role of circular RNAs (circRNAs) in neuropathic pain is linked to the fundamental physiological mechanisms involved. However, the exact function...
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Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists
In the 1980s, the identification of specific pharmacological antagonists played a crucial role in enhancing our comprehension of the physiological...
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The Glycolysis Inhibitor 2-Deoxy-d-Glucose Exerts Different Neuronal Effects at Circuit and Cellular Levels, Partially Reverses Behavioral Alterations and does not Prevent NADPH Diaphorase Activity Reduction in the Intrahippocampal Kainic Acid Model of Temporal Lobe Epilepsy
Temporal lobe epilepsy is the most drug-resistant type with the highest incidence among the other focal epilepsies. Metabolic manipulations are of...
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The atypic antipsychotic clozapine inhibits multiple cardiac ion channels
Clozapine is an atypical neuroleptic used to manage treatment-resistant schizophrenia which is known to inhibit cardiac hERG/K V 11.1 potassium...
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Two firing modes and well-resolved Na+, K+, and Ca2+ currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs
We recorded spontaneous extracellular action potentials (eAPs) from rat chromaffin cells (CCs) at 37 °C using microelectrode arrays (MEAs) and...
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Screening Methods for the Evaluation of Diuretics
Diuretics are drugs that promote increase production of urine by augmenting the excretion of sodium and water. Although they are used in a wide range...
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Adenosine A1 receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area
Adenosine A 1 receptors (A 1 R) are widely expressed in hippocampal pyramidal neurons and their presynaptic terminals. It is well known that endogenous...
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GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome
Loss-of-function variants of SCN5A , encoding the sodium channel alpha subunit Nav1.5 are associated with high phenotypic variability and multiple...
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Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss
T-type calcium channelopathies encompass a group of human disorders either caused or exacerbated by mutations in the genes encoding different T-type...
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Single-compartment model of a pyramidal neuron, fitted to recordings with current and conductance injection
For single neuron models, reproducing characteristics of neuronal activity such as the firing rate, amplitude of spikes, and threshold potentials as...
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Biophysical Recording from Adult Hair Cells
Many biophysical recordings from mammalian cochlear hair cell are made using neonatal or relatively juvenile systems. These tissues are often more...
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Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia
Focal cortical dysplasia (FCD) is one of the most common causes of drug-resistant epilepsy. Dysmorphic neurons are the major histopathological...
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Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials
The back-propagating action potential (bpAP) is crucial for neuronal signal integration and synaptic plasticity in dendritic trees. Its properties...
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Genotype-phenotype correlation in CLCN4-related developmental and epileptic encephalopathy
CLCN4 -related disorder is a rare X-linked neurodevelopmental condition with a pathogenic mechanism yet to be elucidated. CLCN4 encodes the vesicular...
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Affecting AMPA Receptor Biophysical Gating Properties with Negative Allosteric Modulators
Glutamatergic chemical synapses mediate excitatory neurotransmission by the ion flow through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid...
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A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice
Excessive self-grooming is an important behavioral phenotype of the stress response in rodents. Elucidating the neural circuit that regulates...
