Abstract
Regarding the low quality of life due to the cognitive complications in the patients with hepatic cirrhosis (HC), the goal of this study was to examine the possible neuroprotective effect of pioglitazone (PIO) on the electrophysiological alterations of hippocampus, a major area of cognition, in the experimental model of bile duct ligation (BDL). We used adult male Wistar rats in the present study to perform BDL or sham surgery. Pioglitazone was administered in BDL rats two weeks after the surgery for the next continuous four weeks. The effects of pioglitazone on BDL-induced electrophysiological alterations of the CA1 pyramidal neurons in the hippocampus were evaluated by whole-cell patch clamp recordings. Our findings demonstrated that chronic administration of PIO could not reverse the electrophysiological changes in the CA1 pyramidal neurons of the hippocampus in BDL rats but could improve the hepatic dysfunction.
Together, the results of this study suggest that PIO administration cannot counteract altered intrinsic properties of the hippocampal neurons which has been shown recently as an involved mechanism of the cognitive impairments in hepatic encephalopathy (HE).
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The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
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Funding for this study was provided by Kerman University of Medical Sciences and Jiroft University of Medical Sciences as a grant for the PhD thesis.
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MT, IA and MSH have conceived and designed the concept and road map of the study, searched the literature, designed the concept map and figures, and drafted the manuscript. VP and AN have critically reviewed the manuscript for its content, originality, usage of English language, and accuracy of interpreted data. MR designed the study, helped in manuscript preparation, and critically reviewed the manuscript. MR is the archival author and attests to the integrity of the original data and the analysis reported in this manuscript. All authors have made substantive contribution and attest to approving the final manuscript.
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Tahamtan, M., Aghaei, I., Shabani, M. et al. Peroxisome proliferator-activated receptor-γ doesn’t modify altered electrophysiological properties of the CA1 pyramidal neurons in a rat model of hepatic cirrhosis. Metab Brain Dis 37, 2687–2697 (2022). https://doi.org/10.1007/s11011-022-01057-7
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DOI: https://doi.org/10.1007/s11011-022-01057-7