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Peri-Ictal and Para-Ictal Psychiatric Phenomena: A Relatively Common Yet Unrecognized Disorder
Patients with epilepsy can experience different neuropsychiatric symptoms related (peri-ictal) or not (interictal) with seizures. Peri-ictal symptoms...
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Effect of testosterone therapy on breast tissue composition and mammographic breast density in trans masculine individuals
BackgroundThe effect of gender-affirming testosterone therapy (TT) on breast cancer risk is unclear. This study investigated the association between...
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Drug Dependence and Abuse
Physical dependence and addiction differ in that addiction causes activation of certain dopaminergic pathways in the mesolimbic system. Addiction...
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Autism and Sexuality
The word autism, derived from the Greek “autòs,” which means “self,” was first used in psychiatry by Eugen Bleuler in 1911, in order to describe one...
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Behavioral and Psychological Changes in Alzheimer’s and Other Neurodegenerative Disorders
Cognitive, executive, and motor dysfunctions are widely regarded as the hallmarks of neurodegeneration. However, behavioral and mental disorders are...
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Kappa Opioid Receptor Ligands and Pharmacology: Diphenethylamines, a Class of Structurally Distinct, Selective Kappa Opioid Ligands
The kappa opioid receptor (KOR), a G protein-coupled receptor, and its endogenous ligands, the dynorphins, are prominent members of the opioid...
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Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review
Rationale & objectives± 3,4-Methylenedioxymethamphetamine (MDMA) and psilocybin are currently moving through the US Food and Drug Administration’s...
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Emotional and Behavioral Symptoms in Neurodegenerative Diseases
The neural system, including the brain and the spinal cord, consists of its structural units, the neurons whose main characteristic is the incapacity...
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Preclinical and clinical pharmacology of brexanolone (allopregnanolone) for postpartum depression: a landmark journey from concept to clinic in neurosteroid replacement therapy
This article describes the critical role of neurosteroids in postpartum depression (PPD) and outlines the landmark pharmacological journey of...
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Neurotoxicity of Exogenous Cannabinoids
The endogenous cannabinoid system regulates diverse aspects of physiological functions via specific cannabinoid receptors (CB) expressed in the brain...
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Cannabis use after a cancer diagnosis in a population-based sample of cancer survivors
PurposeThis study aimed to characterize the prevalence and correlates of cannabis use and the methods and reasons for use among recently diagnosed...
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Molecular Imaging of the Human Emotion Circuit
Emotions modulate behavioral priorities via central and peripheral nervous systems. Understanding emotions from the perspective of specific...
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Massive secretions in paragonimiasis pleural effusion: a new finding concerning clinical recognition and treatment
Some paragonimiasis patients in Chongqing, southwest China, have recently exhibited pleural effusions (PEs) with massive viscous secretions. This...
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The Structure of Catatonia in Depression and Depressive-Delusional States
Objectives. To identify the psychopathological structure of catatonia and highlight its most significant components in depressive and...
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The effect of music therapy on cognitive functions in patients with Alzheimer’s disease: a systematic review of randomized controlled trials
BackgroundThe use of music interventions as a non-pharmacological therapy to improve cognitive and behavioral symptoms in Alzheimer’s disease (AD)...
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Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders
Over three decades of evidence indicate that dopamine (DA) D3 receptors (D3R) are involved in the control of drug-seeking behavior and may play an...
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The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats
RationaleTriazole 1.1 is a novel kappa-opioid receptor (KOR) agonist reported to produce antinociception without KOR-typical adverse effects. When...
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Addiction and Sleep Disorders
Shared neurophysiology of addiction and sleep disorders results in a bidirectional interplay. Diagnosing and treating primary sleep disorders,...
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Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats
RationaleKratom ( Mitragyna speciosa Korth), a native medicinal plant of Southeast Asia, is proposed to exhibit potential therapeutic value as an...
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