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Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a common cause of dementia that is clinically characterized by the loss of memory and cognitive functions. Currently,...
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Determination of Proinflammatory and Antiinflammatory Cytokines by ELISA Technique
The main objective of this chapter is to determine inflammatory and anti-inflammatory cytokines in patients with or without preeclampsia by means of...
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Saliva as a Relevant Biofluid for Huntington’s Disease Biomarker Research
Fluid biomarkers have traditionally been measured in cerebral spinal fluid and blood and the identification of markers in these biofluids has led to...
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Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer
BackgroundThe safety and immunogenicity of JNJ-64041809 (JNJ-809), a live-attenuated, double-deleted Listeria monocytogenes (LADD Lm )-based...
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A Unique Multiplex ELISA to Profile Growth Factors and Cytokines in Cerebrospinal Fluid
Multiplex arrays designed for enzyme-linked immunosorbent assays (ELISAs) are robust and cost-effective for profiling biomarkers. Identification of...
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Induction of Human T Cell Development In Vitro with OP9-DL4-7FS Cells Expressing Human Cytokines
For nearly a generation now, OP9-DL1 and OP9-DL4 cells have provided an efficient and reliable cell system to generate T cells from mouse and human...
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Generation of Murine T Cell Effector Populations In Vitro
Expansion of T cell subsets in vitro is a valuable tool for exploration of effector function and differentiation. Here we provide protocols for in...
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Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis
BackgroundThe interleukin (IL)-36 cytokines are a sub-family of the IL-1 family which are becoming increasingly implicated in the pathogenesis of...
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Multiscale In Silico Modeling of Cartilage Injuries
Injurious loading of the joint can be accompanied by articular cartilage damage and trigger inflammation. However, it is not well-known which...
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Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
BackgroundAging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more...
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Biomarkers of Delirium and Cognitive Impairment
Many mechanisms have been implicated in the pathophysiology of delirium, including neuroinflammation, neuropathological changes associated with...
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Chemokine and Cytokine Network in Angiogenesis
Angiogenesis is a hallmark of cancer and has been the target of new therapies since last few years; however, it is a complex process and involves...
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Salivary cytokines as biomarkers of oral cancer: a systematic review and meta-analysis
BackgroundOral cancer (OC) is usually diagnosed at advanced clinical stages due to its asymptomatic nature and absence of pathognomonic signs in its...
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Therapeutic Implications of Cytokines and Chemokines Network in Cancer
Innate and adaptive immune cells, as well as non-immune cells and tissues, communicate with one another through interleukins and related cytokines....
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A History of Immune and Neuroendocrine System Interactions
The purpose of this chapter is to provide a twentieth century history of neuroendocrine and immune systems and the interactions of their components....
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Gyrolab Immunoassays: Miniaturization, Automation, and Integration into a Rapid Workflow
Gyrolab® is an open immunoassay platform that automates the complete immunoassay protocol in a microfluidic disc. The column profiles generated with...
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Inflammation Resolution Mediators: Future Prospects
Inflammation resolution is a complex system that involves a variety of lipid mediators, proteins, hormones, and gaseous mediators that act in a...
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In Vitro Model Systems to Study Human T Cell Development
Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and...
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Bioactive Metabolites Produced by Fungi Present in Antarctic, Arctic, and Alpine Ecosystems
Hostile and harsh environments to most organisms represent more than 80% of the earth’s surface. These extreme environments shelter interesting...
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Indomethacin Combined with Ciprofloxacin Improves the Prognosis of Mice under Severe Traumatic Infection via the PI3K/Akt Pathway in Macrophages
The prevention and treatment strategies for traumatic infection often focus on the use of antibiotics, while eschew the combined treatment of the...
