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In Vitro Model Systems to Study Human T Cell Development

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T-Cell Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2580))

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Abstract

Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and conditions to mimic and study T cell development in vitro. In this chapter, we provide an overview of the specific aspects that need attention when performing T cell differentiation cultures with human hematopoietic and T cell progenitors.

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Author information

Authors and Affiliations

  1. Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent University Hospital, Ghent, Belgium

    Nina Lambrechts, Kai Ling Liang, Imke Velghe, Steven Strubbe, Anne-Catherine Dolens & Tom Taghon

Authors
  1. Nina Lambrechts
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  2. Kai Ling Liang
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  3. Imke Velghe
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  4. Steven Strubbe
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  5. Anne-Catherine Dolens
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  6. Tom Taghon
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Corresponding author

Correspondence to Tom Taghon .

Editor information

Editors and Affiliations

  1. Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Remy Bosselut

  2. Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Melanie S. Vacchio

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© 2023 This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply

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Lambrechts, N., Liang, K.L., Velghe, I., Strubbe, S., Dolens, AC., Taghon, T. (2023). In Vitro Model Systems to Study Human T Cell Development. In: Bosselut, R., Vacchio, M.S. (eds) T-Cell Development. Methods in Molecular Biology, vol 2580. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2740-2_21

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  • DOI: https://doi.org/10.1007/978-1-0716-2740-2_21

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2739-6

  • Online ISBN: 978-1-0716-2740-2

  • eBook Packages: Springer Protocols

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