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Single nucleotide polymorphisms and the risk of develo** a second primary cancer among head and neck cancer patients: a systematic literature review and meta-analysis
BackgroundHead and Neck Cancer (HNC) survivors are at increased risk of develo** a second primary cancer (SPC). Along with the environmental risk...
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A Pilot Study of Ex Vivo Human Prefrontal RNA Transcriptomics in Parkinson’s Disease
Parkinson’s disease (PD) can dramatically change cortical neurophysiology. The molecular basis for PD-related cortical changes is unclear because...
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Comprehensive Analyses of PANoptosome with Potential Implications in Cancer Prognosis and Immunotherapy
Cell death resistance significantly contributes to poor therapeutic outcomes in various cancers. PANoptosis, a unique inflammatory programmed cell...
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Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells
BackgroundIL-6 plays a pivotal role in resistance to chemotherapeutics, including lobaplatin. However, the underlying mechanisms are still unclear....
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The potential roles of m6A modification in regulating the inflammatory response in microglia
BackgroundMicroglia are key regulators of the inflammatory response in the brain. Adenosine in RNAs can be converted to m 6 A (N 6 -methyladenosine),...
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Methylation as a critical epigenetic process during tumor progressions among Iranian population: an overview
Cancer is one of the main health challenges and leading causes of deaths in the world. Various environmental and genetic risk factors are associated...
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Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis
BackgroundPsoriasis is a chronic and hyperproliferative skin disease featured by hyperkeratosis with parakeratosis, Munro micro-abscess, elongation...
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Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2
BackgroundEndothelial dysfunction plays a central role in the pathophysiology of COVID-19 and is closely linked to the severity and mortality of the...
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Mining prognostic markers of Asian hepatocellular carcinoma patients based on the apoptosis-related genes
BackgroundApoptosis-related genes(Args)play an essential role in the occurrence and progression of hepatocellular carcinoma(HCC). However, few...
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Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units
In this study, pillar[5]arene containing ten terminal alkynyl-functional group was prepared and carried out an optimization procedure for target...
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Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model
BackgroundModifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs...
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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Famotidine promotes inflammation by triggering cell pyroptosis in gastric cancer cells
BackgroundCell pyroptosis has been characterized by cell swelling and pro-inflammatory factors release to aggravate inflammatory reaction., such as...
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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death....
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Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity
Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for...
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The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism
N 6 -adenosine methylation (m 6 A) is critical for controlling cancer cell growth and tumorigenesis. However, the function and detailed mechanism of how m
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Comparative Analysis of Cytotoxic Activity of New Nitrosyl Iron—Sulfur Complexes in Human Tumor Cells In Vitro
We studied cytotoxic activity of new tetranitrosyl NO-generating binuclear iron—sulfur [Fe—S] complexes containing different ligands in the molecule...
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Cannabidiol (CBD) is one of the most prevalent and abundant cannabinoids extracted from the plant Cannabis sativa . CBD has been reported to induce...
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Pseudotime Ordering Single-Cell Transcriptomic of β Cells Pancreatic Islets in Health and Type 2 Diabetes
β cells are defined by the ability to produce and secret insulin. Recent studies have evaluated that human pancreatic β cells are heterogeneous and...
