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Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units

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Abstract

In this study, pillar[5]arene containing ten terminal alkynyl-functional group was prepared and carried out an optimization procedure for target molecule with using 5-hydroxyquinoline molecule known with biological activity. The novel molecule was named as iso-QP[5] and characterized by FT-IR, melting point, NMR, elemental analysis, and mass spectroscopy. The aim was to evaluate the anticancer effects of iso-QP[5] on MCF7 human breast cancer cells. The IC50 dose of iso-QP[5] in MCF7 cells was found to be 25 µM for 24 h using XTT assay. Expressions of eight genes for apoptosis were determined by qPCR. The results showed a significant increase in the expression of BAX, CASP3, CASP9, CYCS, and P53 genes after treatment with iso-QP[5] in MCF7 cells. However, iso-QP[5] treatment significantly decreased expression of BCL2 and CASP8 genes. It is concluded that novel molecule iso-QP[5] caused apoptosis by regulating genes that are important in apoptosis in human breast cancer cells.

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Acknowledgements

The authors express their appreciation to Prof ErsinGuler for helpful discussions. This research was supported by the Scientific Research Projects Foundation of Necmettin Erbakan University (BAP; #1512180023).

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Authors and Affiliations

  1. Department of Medical Biology, Meram Faculty of Medicine, Necmettin Erbakan University, 42080, Konya, Turkey

    Canan Eroglu Gunes & Ercan Kurar

  2. Department of Hematology, Meram Faculty of Medicine Necmettin Erbakan University, 42080, Konya, Turkey

    Mehmet Ali Karaselek

  3. Department of Chemistry, Faculty of Science, Selcuk University, 42250, Konya, Turkey

    Ahmed Nuri Kursunlu & Mustafa Ozmen

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  1. Canan Eroglu Gunes
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  2. Mehmet Ali Karaselek
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  3. Ahmed Nuri Kursunlu
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  4. Mustafa Ozmen
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  5. Ercan Kurar
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Correspondence to Ahmed Nuri Kursunlu.

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Gunes, C.E., Karaselek, M.A., Kursunlu, A.N. et al. Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units. Med Chem Res 29, 1077–1083 (2020). https://doi.org/10.1007/s00044-020-02547-y

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