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Feasibility of a Composite Measure of Pulmonary Vascular Impedance and Application to Patients with Chronic RV Failure Post LVAD Implant
Pulmonary vascular impedance (PVZ) describes RV afterload in the frequency domain and has not been studied extensively in LVAD patients. We sought to...
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A Novel Rheumatic Mitral Valve Disease Model with Ex Vivo Hemodynamic and Biomechanical Validation
PurposeRheumatic heart disease is a major cause of mitral valve (MV) dysfunction, particularly in disadvantaged areas and develo** countries. There...
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Unique Features of the Human Sinoatrial Node Structure, Function, and Arrhythmias: Mechanistic Insights from Integrated 3D Map** Approaches
The sinoatrial node (SAN) is the primary pacemaker in mammalian hearts, which generates intrinsic electrical activation to maintain synchronous and...
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Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent challenge for cardiovascular medicine. It has a poor prognosis,...
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Hypertension: Potential Player in Cardiovascular Disease Incidence in Preeclampsia
Preeclampsia (PE) is one of the complications, that threatens pregnant mothers during pregnancy. According to studies, it accounts for 3–7% of all...
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Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients
In the field of congenital heart surgery, tissue-engineered vascular grafts (TEVGs) are a promising alternative to traditionally used synthetic...
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Multi-Modal in Vitro Experiments Mimicking the Flow Through a Mitral Heart Valve Phantom
PurposeFluid-structure interaction (FSI) models are more commonly applied in medical research as computational power is increasing. However,...
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Molecular Pathways and Animal Models of Cardiomyopathies
Cardiomyopathies are a heterogeneous group of disorders of the heart muscle that ultimately result in congestive heart failure. Rapid progress in...
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Hemodynamics During Development and Postnatal Life
A well-developed heart is essential for embryonic survival. There are constant interactions between cardiac tissue motion and blood flow, which...
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Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia
BackgroundArterial stiffening has emerged as an important risk factor for Alzheimer’s disease (AD) and related dementias. Carotid-femoral pulse wave...
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Renin-Angiotensin System in Chronic Kidney Disease: Implications in Stroke Outcome
Stroke has an intricate pathophysiology and aggravation of that often leads to co-morbidities. Chronic kidney disease is devastating and plays an...
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Evaluation of Local Tissue Reaction After the Application of a 3D Printed Novel Holdfast Device for Left Atrial Appendage Exclusion
The left atrial appendage (LAA) is a small, finger-like extension of the left atrium and its exclusion is used as a treatment strategy to prevent...
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Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use...
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Galectin-3 and soluble RAGE as new biomarkers of post-infarction cardiac remodeling
AbstractPost-infarction remodeling is a clinical problem with no curative treatment. Our objective was to search for new biomarkers of cardiac...
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The Contractile Machines of the Heart
This chapter will describe basic structural and functional features of the contractile apparatus of muscle cells of the heart, namely, cardiomyocytes...
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Genome Editing and Myocardial Development
Congenital heart disease (CHD) has a strong genetic etiology, making it a likely candidate for therapeutic intervention using genetic editing....
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Acausal Modelling of Advanced-Stage Heart Failure and the Istanbul Heart Ventricular Assist Device Support with Patient Data
BackgroundIn object-oriented or acausal modelling, components of the model can be connected topologically, following the inherent structure of the...
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Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
Sleep-disordered breathing (SDB) can be a sequela of stroke caused by vascular injury to vital respiratory centers, cerebral edema, and increased...
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Biventricular Interaction During Acute Left Ventricular Ischemia in Mice: A Combined In-Vivo and In-Silico Approach
Computational models provide an efficient paradigm for integrating and linking multiple spatial and temporal scales. However, these models are...
