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Hemodynamics During Development and Postnatal Life

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Congenital Heart Diseases: The Broken Heart

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1441))

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Abstract

A well-developed heart is essential for embryonic survival. There are constant interactions between cardiac tissue motion and blood flow, which determine the heart shape itself. Hemodynamic forces are a powerful stimulus for cardiac growth and differentiation. Therefore, it is particularly interesting to investigate how the blood flows through the heart and how hemodynamics is linked to a particular species and its development, including human. The appropriate patterns and magnitude of hemodynamic stresses are necessary for the proper formation of cardiac structures, and hemodynamic perturbations have been found to cause malformations via identifiable mechanobiological molecular pathways. There are significant differences in cardiac hemodynamics among vertebrate species, which go hand in hand with the presence of specific anatomical structures. However, strong similarities during development suggest a common pattern for cardiac hemodynamics in human adults. In the human fetal heart, hemodynamic abnormalities during gestation are known to progress to congenital heart malformations by birth. In this chapter, we discuss the current state of the knowledge of the prenatal cardiac hemodynamics, as discovered through small and large animal models, as well as from clinical investigations, with parallels gathered from the poikilotherm vertebrates that emulate some hemodynamically significant human congenital heart diseases.

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Acknowledgments

This study was supported by the Next Generation EU EXCELES, ID: LX22NPO5104, Ministry of Education PROGRES-Q38/LF1/5, Cooperation 207029 Cardiovascular Science, and institutional funding from the Academy of Sciences of the Czech Republic RVO: 67985823. Further support comes from the Grant Agency of the Czech Republic 18-03461S and 22-05271S, and the Czech Health Research Council NU21-02-00402. Royal Society Newton International Fellowship funded under the Newton Fund: NIF\R1\202197.

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Authors and Affiliations

  1. Laboratory of Developmental Cardiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

    Martina Gregorovicova & David Sedmera

  2. Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Martina Gregorovicova & David Sedmera

  3. Department of Bioengineering, Imperial College, London, UK

    S. Samaneh Lashkarinia & Choon Hwai Yap

  4. Pediatric Cardiology, Motol University Hospital, Prague, Czech Republic

    Viktor Tomek

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  1. Martina Gregorovicova
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  2. S. Samaneh Lashkarinia
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  3. Choon Hwai Yap
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  4. Viktor Tomek
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  5. David Sedmera
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Correspondence to David Sedmera .

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Editors and Affiliations

  1. Cardiovascular Genetics, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Silke Rickert-Sperling

  2. Developmental Biology, Institut de Biologie du Dévelopment de Marseille, Aix Marseille Université, Marseille, France

    Robert G. Kelly

  3. LMU Ludwig Maximilian University, Klinikum der Universität München, München, Bayern, Germany

    Nikolaus Haas

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Gregorovicova, M., Lashkarinia, S.S., Yap, C.H., Tomek, V., Sedmera, D. (2024). Hemodynamics During Development and Postnatal Life. In: Rickert-Sperling, S., Kelly, R.G., Haas, N. (eds) Congenital Heart Diseases: The Broken Heart. Advances in Experimental Medicine and Biology, vol 1441. Springer, Cham. https://doi.org/10.1007/978-3-031-44087-8_11

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