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  1. Article

    Open Access

    Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

    Aberrant neuroendocrine signaling is frequent yet poorly understood feature of prostate cancers. Membrane metalloendopeptidase (MME) is responsible for the catalytic inactivation of neuropeptide substrates, an...

    Chieh-Yang Cheng, Zongxiang Zhou, Meredith Stone, Bao Lu… in Oncogenesis (2020)

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  2. Article

    Open Access

    Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening

    MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportu...

    Zongxiang Zhou, Manishha Patel, Nicholas Ng, Mindy H Hsieh, Anthony P Orth… in BMC Cancer (2014)

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  3. No Access

    Chapter

    Prostate Stem Cells and Cancer in Animals

    The mouse prostate has been the primary focus of research in regards to both normal stem cells and cancer stem cell-like cell populations in the animal prostate. The proximal region is the probable location of...

    Alexander Yu. Nikitin, Melia G. Nafus, Zongxiang Zhou… in Stem Cells and Cancer (2009)

  4. Article

    Open Access

    Pro-neural transcription factors as cancer markers

    The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiati...

    Maria Vias, Charlie E Massie, Philip East, Helen Scott, Anne Warren… in BMC Medical Genomics (2008)

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  5. No Access

    Article

    Note: Isolation and Characterization of a Jerky and JRK/JH8 Like Gene, Tigger Transposable Element Derived 7, TIGD7

    Tonghai Dou, Shaohua Gu, Zongxiang Zhou, Chaoneng Ji, Li Zeng… in Biochemical Genetics (2004)

  6. No Access

    Article

    A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissuesa

    We report the cloning and characterization of a novel human hydroxysteroid dehydrogenase like gene (HSDL1) located on human chromosome 16q24.2. The HSDL1 cDNA is 3407 base pair in length, encoding a 309 amino ...

    Yan Huang, Rong Tang, Jianfeng Dai, Shaohua Gu, Wei Zhao… in Molecular Biology Reports (2001)

  7. No Access

    Article

    Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain

    Short-chain dehydrogenases/reductases (SDR) constitute a large protein family of NAD(P)(H)-dependent oxidoreductase. They are defined by distinct, common sequence motifs and show a wide range of substrate spec...

    Qihan Wu, Ming Xu, Chao Cheng, Zongxiang Zhou, Yan Huang… in Molecular Biology Reports (2001)

  8. No Access

    Article

    Cloning and Characterization of KLHL5, a Novel Human Gene Encoding a Kelch-Related Protein with a BTB Domain

    Most kelch family proteins contain two conserved domains, the BTB domain and the kelch repeat domain. Here we describe the cloning and characterization of a novel human KLHL5 gene. The 3488 bp cDNA encodes a kelc...

    Shu Wang, Zongxiang Zhou, Kang Ying, Rong Tang, Yan Huang… in Biochemical Genetics (2001)

  9. No Access

    Article

    Identification of a Human LNX Protein Containing Multiple PDZ Domains

    Recently PDZ5 domains have been recognized as crucial organizers of protein complexes at the plasma membrane. Here we report the cloning of a novel 3.7-kb cDNA LNX from a human fetal brain cDNA library. The deduc...

    Yi **e, Wei Zhao, Wei Wang, Sihui Zhao, Rong Tang, Kang Ying… in Biochemical Genetics (2001)