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Article
Open AccessInvestigating the use of finerenone in children with chronic kidney disease and proteinuria: design of the FIONA and open-label extension studies
Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat ...
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Article
Intrapersonal and Organisational Predictors of Psychological Help-Seeking in a UK Police Force
Police officers experience multiple operational, organisational, and contextual stressors, which impact wellbeing and have significant repercussions for the economy and public safety. However, officers often f...
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Article
Open AccessAZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins
We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial network. To investigate the actions of this class o...
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Article
Open AccessIndependence of HIF1a and androgen signaling pathways in prostate cancer
Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...
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Article
Open AccessiCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function
SAFB1 is a RNA binding protein implicated in the regulation of multiple cellular processes such as the regulation of transcription, stress response, DNA repair and RNA processing. To gain further insight into ...
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Article
Open AccessDe-tabooing dying control - a grounded theory study
Dying is inescapable yet remains a neglected issue in modern health care. The research question in this study was “what is going on in the field of dying today?” What emerged was to eventually present a ground...
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Article
Open AccessPro-neural transcription factors as cancer markers
The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine differentiati...
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Article
Open AccessA comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects
Periconceptional use of vitamin supplements containing folic acid reduces the risk of a neural tube defect (NTD). In November 1998, food fortification with folic acid was mandated in Canada, as a public health...
