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Article
Insight into the role of a trans-AT polyketide synthase in the biosynthesis of lankacidin-type natural products
Modular polyketide synthases (type I PKSs) are biosynthetic assembly lines for synthesizing a diverse array of natural products. While most PKSs exhibit a linear module architecture, the PKS system for lankaci...
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Article
Discovery and biosynthetic pathway analysis of cyclopentane–β-lactone globilactone A
Naturally occurring β-lactone compounds are a class of strained four-membered heterocycles and can act as highly reactive electrophiles. Despite intensive studies for several decades, fewer than 30 β-lactones,...
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Article
Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454
Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscop...