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  1. Article

    Open Access

    Clinicopathological characteristics, survival outcomes and prognostic factors in pleomorphic carcinoma: a SEER population-based study

    Pulmonary pleomorphic carcinoma (PPC) is a rare tumor, and it usually has an aggressive clinical course and poor prognosis. We aim to analyze the clinicopathological features, management and prognostic factors...

    Zhongzhong Chen, Jiachang Liu, Lingfeng Min in BMC Pulmonary Medicine (2022)

  2. Article

    Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants

    A Correction to this paper has been published: https://doi.org/10.1038/s41422-021-00475-z

    Zhongzhong Chen, Yun** Lei, Yufang Zheng, Vanessa Aguiar-Pulido in Cell Research (2021)

  3. Article

    Open Access

    Correction to: Genetic analysis of Wnt/PCP genes in neural tube defects

    An amendment to this paper has been published and can be accessed via the original article.

    Zhongzhong Chen, Yun** Lei, Xuanye Cao, Yufang Zheng, Fang Wang in BMC Medical Genomics (2021)

  4. Article

    Open Access

    Rare cause of repeated pulmonary embolism: a case of primary pleural squamous cell carcinoma and literature review

    Malignant tumors are risk factors for a pulmonary embolism (PE), and a PE caused by a tumor is not uncommon. Primary pleural squamous cell carcinoma (PPSCC) is a rare malignancy; thus, a related PE is extremel...

    Zhongzhong Chen, Tingting Feng, Meng Wang, **ngxiang Xu in BMC Pulmonary Medicine (2020)

  5. Article

    Open Access

    Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13

    Hypospadias risk–associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs). There is little known at present about any possible hypospadias ri...

    Zhongzhong Chen, **aoling Lin, Yun** Lei, Haitao Chen in BMC Medical Genomics (2019)

  6. Article

    Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Zhongzhong Chen, Yun** Lei, Yufang Zheng, Vanessa Aguiar-Pulido in Cell Research (2019)

  7. No Access

    Article

    Map** phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

    Phosphorylation networks intimately regulate mechanisms of response to therapies. Map** the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-t...

    Jean-Philippe Coppé, Miki Mori, Bo Pan, Christina Yau in Nature Cell Biology (2019)

  8. Article

    Open Access

    Threshold for neural tube defect risk by accumulated singleton loss-of-function variants

    Zhongzhong Chen, Yun** Lei, Yufang Zheng, Vanessa Aguiar-Pulido in Cell Research (2018)

  9. Article

    Open Access

    Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor

    Primary malignant cardiac tumors (PMCTs) are extremely rare. The apparent immunity of the heart to invasive cancer has attracted considerable interest given the continuously rising incidence of cancer in other...

    **angyu Zhou, Mengjia Xu, Weijia Zeng, Zhongzhong Chen, Guohui Lu in Cell Death Discovery (2018)

  10. Article

    Open Access

    Genetic analysis of Wnt/PCP genes in neural tube defects

    Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube clo...

    Zhongzhong Chen, Yun** Lei, Xuanye Cao, Yufang Zheng, Fang Wang in BMC Medical Genomics (2018)

  11. No Access

    Article

    Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort

    Neural tube defects (NTDs), which include spina bifida and anencephaly, are the second most common form of human structural congenital malformations. While it is well established that SHROOM3 plays a pivotal role...

    Zhongzhong Chen, Lele Kuang, Richard H. Finnell, Hongyan Wang in Human Genetics (2018)

  12. Article

    Open Access

    Comparative proteomic analysis reveals alterations in development and photosynthesis-related proteins in diploid and triploid rice

    Polyploidy has pivotal influences on rice (Oryza sativa L.) morphology and physiology, and is very important for understanding rice domestication and improving agricultural traits. Diploid (DP) and triploid (TP) ...

    Shuzhen Wang, Wenyue Chen, Changdeng Yang, Jian Yao, in BMC Plant Biology (2016)

  13. Article

    Open Access

    GeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks

    Virtually all cellular functions involve protein-protein interactions (PPIs). As an increasing number of PPIs are identified and vast amount of information accumulated, researchers are finding different ways t...

    Zhongzhong Chen, Tianhong Zhang, Jun Lin, Zidan Yan, Yongren Wang in Scientific Reports (2014)