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Open AccessClinicopathological characteristics, survival outcomes and prognostic factors in pleomorphic carcinoma: a SEER population-based study
Pulmonary pleomorphic carcinoma (PPC) is a rare tumor, and it usually has an aggressive clinical course and poor prognosis. We aim to analyze the clinicopathological features, management and prognostic factors...
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Article
Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants
A Correction to this paper has been published: https://doi.org/10.1038/s41422-021-00475-z
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Open AccessCorrection to: Genetic analysis of Wnt/PCP genes in neural tube defects
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessRare cause of repeated pulmonary embolism: a case of primary pleural squamous cell carcinoma and literature review
Malignant tumors are risk factors for a pulmonary embolism (PE), and a PE caused by a tumor is not uncommon. Primary pleural squamous cell carcinoma (PPSCC) is a rare malignancy; thus, a related PE is extremel...
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Article
Open AccessGenome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13
Hypospadias risk–associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs). There is little known at present about any possible hypospadias ri...
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Article
Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Map** phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities
Phosphorylation networks intimately regulate mechanisms of response to therapies. Map** the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-t...
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Open AccessThreshold for neural tube defect risk by accumulated singleton loss-of-function variants
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Article
Open AccessCombined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor
Primary malignant cardiac tumors (PMCTs) are extremely rare. The apparent immunity of the heart to invasive cancer has attracted considerable interest given the continuously rising incidence of cancer in other...
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Article
Open AccessGenetic analysis of Wnt/PCP genes in neural tube defects
Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube clo...
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Article
Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort
Neural tube defects (NTDs), which include spina bifida and anencephaly, are the second most common form of human structural congenital malformations. While it is well established that SHROOM3 plays a pivotal role...
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Article
Open AccessComparative proteomic analysis reveals alterations in development and photosynthesis-related proteins in diploid and triploid rice
Polyploidy has pivotal influences on rice (Oryza sativa L.) morphology and physiology, and is very important for understanding rice domestication and improving agricultural traits. Diploid (DP) and triploid (TP) ...
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Open AccessGeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks
Virtually all cellular functions involve protein-protein interactions (PPIs). As an increasing number of PPIs are identified and vast amount of information accumulated, researchers are finding different ways t...