-
Article
Open AccessA Whole-Process Visible Strategy for the Preparation of Rhizomucor miehei Lipase with Escherichia coli Secretion Expression System and the Immobilization
Rhizomucor miehei (RM) lipase is a regioselective lipase widely used in food, pharmaceutical and biofuel industries. However, the high cost and low purity of the commercial RM lipase limit its industrial applicat...
-
Article
Open AccessRAGE plays key role in diabetic retinopathy: a review
RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the retina. Diabetic retin...
-
Article
Open AccessReference-based genome compression using the longest matched substrings with parallelization consideration
A large number of researchers have devoted to accelerating the speed of genome sequencing and reducing the cost of genome sequencing for decades, and they have made great strides in both areas, making it easie...
-
Article
NanoSIMS U–Pb dating of hydrothermally altered monazite: constraints on the timing of the Laozhaiwan Carlin-type gold deposit
To explain the origin of the Carlin-type gold deposit, it is vital to understand their ore-forming chronology. However, the metallogenic age of the deposit remains controversial because of its inadequate tradi...
-
Article
SnO Nanosheets As an Efficient Electrocatalyst for Carbon Dioxide Reduction
Electrochemical carbon dioxide (CO2) reduction to fuels or chemicals is a promising route to offset the over discharged CO2, where efficient electrocatalysts are desirable. In this study, we synthesized SnO nanos...
-
Article
Association Between Regular Blood Pressure Monitoring and the Risk of Intracranial Aneurysm Rupture: a Multicenter Retrospective Study with Propensity Score Matching
Although hypertension is a known risk factor for intracranial aneurysm rupture, the benefit of the management of blood pressure in reducing the rupture risk of intracranial aneurysms remains largely unknown, e...
-
Article
Open AccessCMIC: an efficient quality score compressor with random access functionality
Over the past few decades, the emergence and maturation of new technologies have substantially reduced the cost of genome sequencing. As a result, the amount of genomic data that needs to be stored and transmi...
-
Article
SDF-1α/CXCR4 Pathway Mediates Hemodynamics-Induced Formation of Intracranial Aneurysm by Modulating the Phenotypic Transformation of Vascular Smooth Muscle Cells
The objective of this study is to explore the role of the SDF-1α/CXCR4 pathway in the development of intracranial aneurysm (IA) induced by hemodynamic forces. We collected 12 IA and six superficial temporal ar...
-
Article
Open AccessUnderlying mechanism of hemodynamics and intracranial aneurysm
In modern society, subarachnoid hemorrhage, mostly caused by intracranial aneurysm rupture, is accompanied by high disability and mortality rate, which has become a major threat to human health. Till now, the ...
-
Article
A rapid reduction of Au(I→0) strategy for the colorimetric detection and discrimination of proteins
A gold nanoparticle (AuNP)–based sensing strategy based on rapid reduction of Au(I→0) is proposed. As a proof-of-concept study, the proposed sensing principle is designed for simultaneous and colorimetric dete...
-
Article
The development and understanding of intracranial aneurysm based on rabbit model
In modern society, intracranial aneurysms have seriously affected people’s life. To better study and treat intracranial aneurysm, animal models are ideal candidates to perform biological research and preclinic...
-
Article
Open AccessPrognostic factors for ARDS: clinical, physiological and atypical immunodeficiency
Risk factors affecting the prognosis of acute respiratory distress syndrome (ARDS) in adults were investigated. The aim was to identify new predictors for ARDS patient prognosis, including those with clinical,...
-
Article
Open AccessMyofibroblast induces hepatocyte-to-ductal metaplasia via laminin–ɑvβ6 integrin in liver fibrosis
Hepatocytes undergo the metaplasia into ductal biliary epithelial cells (BECs) in response to chronic injury, and subsequently contribute to liver regeneration. The mechanism underlying hepatocyte-to-ductal me...
-
Article
Sub-10-nm multicolored gold nanoparticles for colorimetric determination of antibiotics via formation of interlocking rings
A general approach is presented for synthesis of multicolored gold nanoparticles (GNPs) by Au(I)-mediated generation of interlocking rings in proteins and antibiotics. The Au(I) ions are shuttled from proteins...
-
Article
Experimental Study of Phase Relations in the Mg-Er-Si System Focused on Mg-Rich Region at 300 and 400 °C
The phase equilibria and compositions in the magnesium (Mg) rich part of the Mg-Er-Si ternary system at 300 and 400 °C were systemically investigated through the equilibrated alloy method by using x-ray diffra...
-
Article
Open Accessβ2 spectrin-mediated differentiation repressed the properties of liver cancer stem cells through β-catenin
βII-Spectrin (β2SP), a Smad3/4 adaptor protein during transforming growth factor (TGF) β/Smad signal pathway, plays a critical role in suppressing hepatocarcinogenesis. Dedifferentiation is a distinctive featu...
-
Article
The effects of colorimetric detection of heavy metal ions based on Au nanoparticles (NPs): size and shape—a case of Co2+
The different sized and shaped Au NPs have intrigued considerable attention, because they possess different surface plasma resonance (SPR) absorption bands and thus result in many colorimetric Au NP-based dete...
-
Article
Open AccessDiagnostic performance of Contrast-enhanced CT in Pyrrolizidine Alkaloids-induced Hepatic Sinusoidal Obstructive Syndrome
Hepatic sinusoidal obstruction syndrome (HSOS) can be caused by pyrrolizidine alkaloids(PAs)-containing herbals. Since PAs exposure is obscure and clinical presentation of HSOS is unspecific, it is challenge t...
-
Article
Probing the structures, stabilities, and electronic properties of neutral and charged carbon-doped lithium CLi n μ (n = 2–20, μ = 0, ±1) clusters from unbiased CALYPSO method
The structural and electronic properties of the global minimum structures of neutral, anionic and cationic CLi n μ ...
-
Article
Open AccessProtein-directed synthesis of highly monodispersed, spherical gold nanoparticles and their applications in multidimensional sensing
An in-situ reduction method has been reported to prepare gold nanoparticles (GNPs) of 40–110 nm by using the green reducing agents of proteins, which are activated by H2O2 and the superoxide anion ( ...
