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Article
Open AccessTyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling
The alteration of metabolic processes has been found to have significant impacts on the development of hepatocellular carcinoma (HCC). Nevertheless, the effects of dysfunction of tyrosine metabolism on the dev...
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Article
Open AccessYersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell subpopulations
Disease-causing bacteria secrete numerous toxins to invade and subjugate their hosts. Unlike many smaller toxins, the secretion machinery of most large toxins remains enigmatic. By combining genomic editing, p...
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Article
Open AccessStructure of the native myosin filament in the relaxed cardiac sarcomere
The thick filament is a key component of sarcomeres, the basic units of striated muscle1. Alterations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and muscle...
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Chapter and Conference Paper
Re-thinking and Re-labeling LIDC-IDRI for Robust Pulmonary Cancer Prediction
The LIDC-IDRI database is the most popular benchmark for lung cancer prediction. However, with subjective assessment from radiologists, nodules in LIDC may have entirely different malignancy annotations from t...
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Chapter and Conference Paper
Interpretable Lung Cancer Diagnosis with Nodule Attribute Guidance and Online Model Debugging
Accurate nodule labeling and interpretable machine learning are important for lung cancer diagnosis. To circumvent the label ambiguity issue of commonly-used unsure nodule data such as LIDC-IDRI, we constructe...
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Article
Lung sparing left secondary carina resection for low-grade tumors: a single-center study
Left-side secondary carina resection and reconstruction is a rare, complex procedure, performed just in a few specialized centers in a restricted group of patients. Few studies describe this technique and repo...
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Article
Modulation of septin higher-order structure by the Cdc28 protein kinase
Septins are a family of eukaryotic guanosine phosphate-binding proteins that form linear heterooligomeric complexes, which, in turn, polymerize end-on-end into filaments. These filaments further assemble into ...
