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Article
Mutation detection and inhibitor analysis of 43 children with severe hemophilia A in a single center: three novel mutations
To investigate the risk factors of FVIII inhibitors development in severe hemophilia A (HA) patients who were received on-demand therapy and were infused with plasma cryoprecipitate and multiple FVIII concentr...
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Article
Open AccessThe association between serum interleukin-1 beta and heparin sulphate in diabetic nephropathy patients
Inflammation is considered an important mechanism in the development of diabetes mellitus (DM) and persists for a long time before the occurrence of diabetic nephropathy (DN). Many studies have demonstrated th...
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Article
Open AccessA novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13
We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and A...
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Article
Open AccessMutations in the D1 domain of von Willebrand factor impair their propeptide-dependent multimerization, intracellular trafficking and secretion
We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. Al...
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Article
Influences of Nano-TiO2 on the chloroplast aging of spinach under light
The effects of nano-TiO2 (rutile) on the chloroplast aging of spinach under light were studied. The results showed that when the chloroplasts were illuminated for 1, 5, and 10 min with 500 μmol/cm2/min light inte...
