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Article
Effects of Freezing and Radio Frequency Tempering on Quality Characteristics of Marinated Yellow-Fin Tuna (Thunnus Albacares)
Temperature fluctuation is recognized as a significant factor contributing to the degradation of frozen fish quality. In this study, we investigated the impact of freeze—radio frequency (RF) temper cycles on v...
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Article
Law of respirable dust pollution induced by cutting-advancing support in a fully mechanized mining face and spatial stereoscopic dust control and removal technology
To reduce the impact of high-concentration RD on the physical and mental health of miners, numerical simulations were conducted on the coupling movement law of airflow-RD under the condition of cutting-advanci...
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Article
Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. Polo-like kinase 1 (PLK1), a member of the serine/threonine kinase PLK family, is the most investigated and essential in the regulation ...
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Article
G6PD activation in TNBC cells induces macrophage recruitment and M2 polarization to promote tumor progression
Glucose-6-phosphate dehydrogenase (G6PD) is involved in triple-negative breast cancer (TNBC) progression. Metabolic crosstalk between cancer cells and tumor-associated macrophages mediates tumor progression in...
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Article
Open AccessTargeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM)
Lymphangioleiomyomatosis (LAM), a progressive pulmonary disease exclusively affecting females, is caused by defects or mutations in the coding gene tuberous sclerosis complex 1 (TSC1) or TSC2, causing the mammali...
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Article
Association of CD27 and CD70 gene polymorphisms with risk of sporadic breast cancer in Chinese women in Heilongjiang Province
CD27 and its ligand, CD70, are major costimulatory molecules whose interaction can regulate the expansion and differentiation of effector and memory T-cell populations. Their abnormal expression can disturb th...
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Article
Association of CTLA-4 gene polymorphisms with sporadic breast cancer risk and clinical features in Han women of Northeast China
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory molecule that plays a pivotal role in downregulating T-cell mediated immune responses. To determine the role of CTLA-4 in tumor immunity, and to valid...
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Article
Open AccessICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study
Inducible costimulator (ICOS), a costimulatory molecular of the CD28 family, provides positive signal to enhance T cell proliferation. Its abnormal expression can disturb the immune response and entail an increa...
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Article
PD-1 polymorphisms are associated with sporadic breast cancer in Chinese Han population of Northeast China
The programmed death-1 (PD-1) is a potent immunoregulatory molecule which is responsible for the negative regulation of T-cell activation and peripheral tolerance. In order to investigate the association betwe...
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Article
LFA-1 gene polymorphisms are associated with the sporadic infiltrative duct breast carcinoma in Chinese Han women of Heilongjiang Province
The infiltrative duct carcinoma (IDC) is the most common malignant breast cancer in females and genetic factors appear to play a significant role in the susceptibility of IDC. The LFA-1 is a crucial co-stimula...
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Article
Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis
Several molecular epidemiological studies were conducted in recent years to evaluate the association between NQO1 Pro187Ser polymorphism and breast cancer risk in diverse populations. However, the results rema...
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Article
Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province
B and T lymphocyte attenuator (BTLA) is an immunoinhibitory receptor with the ability to deliver inhibitory signals for suppressing lymphocyte activation. To identify the influences of BTLA gene polymorphisms ...
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Article
Open AccessB7-H4gene polymorphisms are associated with sporadic breast cancer in a Chinese Han population
B7-H4, a co-inhibitory molecule of the B7 family, can restrain T cell proliferation, cytokine secretion and the development of cytotoxicity. B7-H4 is expressed in tumor tissues at a higher level than in normal...
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Article
Open AccessAssociation of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population
The host immunogenetic background plays an important role in the development of breast cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed predominantly on activated T cells and is import...
