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  1. Article

    Open Access

    p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme

    Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the survival and prognosis of GBM. Although numerous regulatory mechanisms that c...

    Jiao Meng, Wei Qian, Zhenkun Yang, Lingli Gong, Daxing Xu, Hongbo Huang… in BMC Cancer (2024)

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  2. No Access

    Article

    Identification of DNA variants at ultra-low variant allele frequencies via Taq polymerase cleavage of wild-specific blockers

    Detecting mutations related to tumors holds immense clinical significance for cancer diagnosis and treatment. However, the presence of highly redundant wild DNA poses a challenge for the advancement of low-cop...

    Zhaocheng Liu, **ushuai Li, Rui Zhang, Li Ji… in Analytical and Bioanalytical Chemistry (2023)

  3. Article

    Open Access

    Characterization of EGFR-reprogrammable temozolomide-resistant cells in a model of glioblastoma

    Temozolomide (TMZ) resistance is a major clinical challenge for glioblastoma (GBM). O6-methylguanine-DNA methyltransferase (MGMT) mediated DNA damage repair is a key mechanism for TMZ resistance. However, MGMT-nu...

    Lingli Gong, Ying Yin, Cheng Chen, Quan Wan, Die **a, Mei Wang… in Cell Death Discovery (2022)

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  4. No Access

    Article

    Whole-Exome Sequencing Reveals Novel Genetic Variation for Dilated Cardiomyopathy in Pediatric Chinese Patients

    Dilated cardiomyopathy (DCM) is characterized by left or bilateral ventricular dilation and systolic dysfunction without rational conditions, which can lead to progressive heart failure and sudden cardiac deat...

    Genyin Dai, Zhening Pu, Xueying Cheng, Jie Yin, Jun Chen, Ting Xu… in Pediatric Cardiology (2019)

  5. No Access

    Article

    Integrating of genomic and transcriptomic profiles for the prognostic assessment of breast cancer

    To evaluate the prognostic effect of the integration of genomic and transcriptomic profiles in breast cancer.

    Chengxiao Yu, Na Qin, Zhening Pu, Ci Song… in Breast Cancer Research and Treatment (2019)

  6. Article

    Open Access

    Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients

    Chinese lung cancer patients have distinct epidemiologic and genomic features, highlighting the presence of specific etiologic mechanisms other than smoking. Here, we present a comprehensive genomic landscape ...

    Cheng Wang, Rong Yin, Juncheng Dai, Yayun Gu, Shaohua Cui… in Nature Communications (2018)

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