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  1. No Access

    Article

    Minimally Toxic Dose of Lipopolysaccharide and α-Synuclein Oligomer Elicit Synergistic Dopaminergic Neurodegeneration: Role and Mechanism of Microglial NOX2 Activation

    The aim of this study is to investigate the role and mechanism of microglial NOX2 activation in minimally toxic dose of LPS and Syn-elicited synergistic dopaminergic neurodegeneration. NOX2+/+ and NOX2−/− mice an...

    Wei Zhang, Jun-hua Gao, Zhao-fen Yan, **-yan Huang, Peng Guo… in Molecular Neurobiology (2018)

  2. No Access

    Article

    Role and Mechanism of Microglial Activation in Iron-Induced Selective and Progressive Dopaminergic Neurodegeneration

    Parkinson’s disease (PD) patients have excessive iron depositions in substantia nigra (SN). Neuroinflammation characterized by microglial activation is pivotal for dopaminergic neurodegeneration in PD. However...

    Wei Zhang, Zhao-fen Yan, Jun-hua Gao, Li Sun, **-yan Huang… in Molecular Neurobiology (2014)