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Article
A cross-species proteomic map reveals neoteny of human synapse development
The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood1,2. Here we generate a cross-species proteomic map of synapse development in the human, macaque and m...
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Article
Loss of the Maternal Effect Gene Nlrp2 Alters the Transcriptome of Ovulated Mouse Oocytes and Impacts Expression of Histone Demethylase KDM1B
The subcortical maternal complex (SCMC) is a multiprotein complex in oocytes and preimplantation embryos that is encoded by maternal effect genes. The SCMC is essential for zygote-to-embryo transition, early e...
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Article
MCANet: multi-scale contextual feature fusion network based on Atrous convolution
In past studies, atrous convolution is efficient in segmentation tasks to reinforce the receptive field and detection tasks. In addition, the attention module is efficient for feature extraction and enhancemen...
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Article
Open AccessCorrection: Single-cell multi-omics integration for unpaired data by a siamese network with graph-based contrastive loss
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Article
Open AccessSingle-cell multi-omics integration for unpaired data by a siamese network with graph-based contrastive loss
Single-cell omics technology is rapidly develo** to measure the epigenome, genome, and transcriptome across a range of cell types. However, it is still challenging to integrate omics data from different moda...
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Article
Open AccessRegion-specific denoising identifies spatial co-expression patterns and intra-tissue heterogeneity in spatially resolved transcriptomics data
Spatially resolved transcriptomics is a relatively new technique that maps transcriptional information within a tissue. Analysis of these datasets is challenging because gene expression values are highly spars...
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Article
Recalibrating plant water status of winter wheat based on nitrogen nutrition index using thermal images
Accurate and timely assessment of crop water status is imperative for in-season irrigation scheduling in crop production. The canopy water stress index and water deficit index have been widely used to appraise...
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Article
Open AccessA benchmark for RNA-seq deconvolution analysis under dynamic testing environments
Deconvolution analyses have been widely used to track compositional alterations of cell types in gene expression data. Although a large number of novel methods have been developed, due to a lack of understandi...
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Article
Open AccessStress detection using deep neural networks
Over 70% of Americans regularly experience stress. Chronic stress results in cancer, cardiovascular disease, depression, and diabetes, and thus is deeply detrimental to physiological health and psychological w...
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Article
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability
Neurons are sensitive to changes in the dosage of many genes, especially those regulating synaptic functions. Haploinsufficiency of SHANK3 causes Phelan-McDermid syndrome and autism, whereas duplication of the sa...
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Article
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
Genome sequencing has revealed an increasing number of genetic variations that are associated with neuropsychiatric disorders. Frequently, studies limit their focus to likely gene-disrupting mutations because ...
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Article
Open AccessIntegrated analysis of the aging brain transcriptome and proteome in tauopathy
Tau neurofibrillary tangle pathology characterizes Alzheimer’s disease and other neurodegenerative tauopathies. Brain gene expression profiles can reveal mechanisms; however, few studies have systematically ex...
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Article
Structural Equation Modeling of Soil Moisture Effects on Evapotranspiration of Maize in the North China Plain
Relationships between crop evapotranspiration (ET) and soil water content (SWC) have been studied worldwide. However, traditional data processing has drawbacks in modeling the contribution of SWC to ET on a la...
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Article
Author Correction: Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus–CA3 projection
In the version of this article initially published, the Acknowledgements erroneously included a grant number that did not directly support the work in the article. The last sentence of the Acknowledgments shou...
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Article
Scene text detection with fully convolutional neural networks
Text detection in scene image has become a hot topic in computer vision and artificial intelligence research, due to its wide range of applications and challenges. Most state-of-the-art methods for text detect...
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Article
Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus–CA3 projection
Nuclear receptor corepressor 1 (NCOR1) and NCOR2 (also known as SMRT) regulate gene expression by activating histone deacetylase 3 through their deacetylase activation domain (DAD). We show that mice with DAD ...
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Article
Open AccessMetabolomics of mammalian brain reveals regional differences
The mammalian brain is organized into regions with specific biological functions and properties. These regions have distinct transcriptomes, but little is known whether they may also differ in their metabolome...
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Article
Open AccessApparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
Recent studies have suggested that genes longer than 100 kb are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-depe...
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Article
Genome-wide distribution of linker histone H1.0 is independent of MeCP2
Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of F...
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Article
Open AccessThe International Conference on Intelligent Biology and Medicine (ICIBM) 2016: from big data to big analytical tools
The 2016 International Conference on Intelligent Biology and Medicine (ICIBM 2016) was held on December 8–10, 2016 in Houston, Texas, USA. ICIBM included eight scientific sessions, four tutorials, one poster s...
