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Article
Torque Improvement and Analysis of a Bearingless Switched Reluctance Motor Under Efficient Levitation Excitation
In a bearingless switched reluctance motor (BSRM), there is a conflict between the output regions of effective radial force and positive torque. So a compromise between radial force and torque is usually appli...
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Article
Open AccessKRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer
The optimal laboratory assay for detecting KRAS mutations in different biospecimens from patients with metastatic colorectal cancer (mCRC), and the clinical relevance of these gene alterations is still in questio...
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Article
Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain
The aim of this study is to evaluate the pharmacokinetic profile of oxycodone and three of its metabolites, noroxycodone, oxymorphone and noroxymorphone after intravenous administration in Chinese patients wit...
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Article
Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases
High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumferenc...
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Article
Simultaneous Determination of Hydrocodone, and Its Two Metabolites in Human Plasma by HPLC–MS–MS
A rapid, sensitive and specific assay method has been developed to simultaneously determine human plasma concentrations of hydrocodone and its metabolites, norhydrocodone, hydromorphone, using high-performance...
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Article
Pharmacokinetics and safety of a new bioengineered thrombolytic agent, human tissue urokinase type plasminogen activator in Chinese healthy volunteers
The aim of our study was to investigate the pharmacokinetics and safety of human tissue urokinase type plasminogen activator (HTUPA) in healthy Chinese subjects after intravenous administration. Thirty-two sub...
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Article
Bioanalysis of Cepharanthine by LC–ESI–MS–MS and Its Application to Pharmacokinetic Studies
A sensitive liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS–MS) method was developed and validated for the quantification of cepharanthine (CEP) in beagle dog plasma. The chro...
