98 Result(s)

Article

Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo

Synaptic loss is an early event in the penumbra area after an ischemic stroke. Promoting synaptic preservation in this area would likely improve functional neurological recovery. We aimed to detect proteins in...

Yuqi Gui, Yohan Kim, Santra Brenna… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Ensemble learning-based gene signature and risk model for predicting prognosis of triple-negative breast cancer

Tiancheng Li, Siqi Chen, Yuqi Zhang, Qianqian Zhao… in Functional & Integrative Genomics (2024)

Article

SLIT3 knockdown inhibited TGF-β-induced hepatic stellate cells activation by down-regulating YAP signal

Liver fibrosis is a chronic liver disease caused by a variety of pathophysiological. However, there are no effective treatments to combat it. HSCs are a major source of fibrotic cells and exploring the mechani...

**ling Fu, Jiabao Chang, Damin Jiao, Mengying Zhu… in Molecular & Cellular Toxicology (2024)

Article

Role of protein degradation systems in colorectal cancer

Protein degradation is essential for maintaining protein homeostasis. The ubiquitin‒proteasome system (UPS) and autophagy–lysosome system are the two primary pathways responsible for protein degradation and di...

Zihan Cui, Mingqi Cong, Shengjie Yin, Yuqi Li, Yuguang Ye, ** Liu… in Cell Death Discovery (2024)

Article

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes multi-organ damage, which includes hepatic dysfunction, as observed in over 50% of COVID-19 patients. Angiotensin I converting enzyme (peptid...

**nyi Yang, Xu Zheng, Yuqi Zhu, **aying Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Gasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD...

Weilv Xu, Qiao **, **nyue Li, Danyue Li, **nyu Fu, Nan Chen… in Cell Death & Disease (2024)

Article

Tumorous IRE1α facilitates CD8⁺T cells-dependent anti-tumor immunity and improves immunotherapy efficacy in melanoma

Tumor cells frequently suffer from endoplasmic reticulum (ER) stress. Previous studies have extensively elucidated the role of tumorous unfolded protein response in melanoma cells, whereas the effect on tumor ...

Yuqi Yang, Sijia Wang, **ang-xu Wang, Sen Guo… in Cell Communication and Signaling (2024)

Article

14–3-3ε: a protein with complex physiology function but promising therapeutic potential in cancer

Over the past decade, the role of the 14–3-3 protein has received increasing interest. Seven subtypes of 14–3-3 proteins exhibit high homology; however, each subtype maintains its specificity. The 14–3-3ε prot...

Yue Zhang, Man Yan, Yongjun Yu, Jiang** Wang… in Cell Communication and Signaling (2024)

Article

Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression

The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironme...

Kang Lin, Yun Zhao, Yuqi Tang, Ying Chen, Moubin Lin, Luwei He in Cell Death & Disease (2024)

Article

HOOK3 suppresses proliferation and metastasis in gastric cancer via the SP1/VEGFA axis

HOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains incomplet...

Kexi Yang, Juntao Li, **ghan Zhu, Yuqi Chen, Yuxin He, Jiayu Wang… in Cell Death Discovery (2024)

Article

Prognostic biomarker discovery based on proteome landscape of Chinese lung adenocarcinoma

Despite recent innovations in imaging and genomic screening promotes advance in diagnosis and treatment of lung adenocarcinoma (LUAD), there remains high mortality of LUAD and insufficient understanding of LUA...

Yuqi Huang, Sheng Ma, Jun-Yu Xu, Kun Qian, Yaru Wang, Yi Zhang… in Clinical Proteomics (2024)

Article

Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage

Primary subarachnoid hemorrhage (SAH) is a type of acute stroke, accounting for approximately 10% of cases, with high disability and mortality rate. Early brain injury (EBI) is a critical factor in determining...

Hanxiao Chang, Zheng Li, Weiwei Zhang, Chao Lin… in Cell Communication and Signaling (2024)

Article

PD-L1 expression levels in mesenchymal stromal cells predict their therapeutic values for autoimmune hepatitis

Autoimmune hepatitis is a chronic inflammatory hepatic disorder with no effective treatment. Mesenchymal stromal cells (MSCs) have emerged as a promising treatment owing to their unique advantages. However, th...

**long Bai, Tingwei Chen, Yuqi Li, **aofan Ge, Caie Qiu… in Stem Cell Research & Therapy (2023)