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Article
Open AccessCollagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression
The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironme...
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Article
CD300ld on neutrophils is required for tumour-driven immune suppression
The immune-suppressive tumour microenvironment represents a major obstacle to effective immunotherapy1,2. Pathologically activated neutrophils, also known as polymorphonuclear myeloid-derived suppressor cells (PM...
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Article
Major genomic mutations driving hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a subtype of highly malignant carcinoma that occurs in the liver, improved understanding of the mechanisms behind HCC tumorigenesis and better clinical treatment options are u...
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Article
Open AccessIdentification of a rare Gli1+ progenitor cell population contributing to liver regeneration during chronic injury
In adults, hepatocytes are mainly replenished from the existing progenitor pools of hepatocytes and cholangiocytes during chronic liver injury. However, it is unclear whether other cell types in addition to cl...
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Article
Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2
The Hedgehog (Hh) signalling pathway plays a critical role in regulating liver lipid metabolism and related diseases. However, the underlying mechanisms are poorly understood. Here, we show that the Hh signall...
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Article
Open AccessPositive feedback between ROS and cis-axis of PIASxα/p38α-SUMOylation/MK2 facilitates gastric cancer metastasis
MAPK/p38 is an important mammalian signaling cascade that responds to a variety of intracellular or extracellular stimuli, such as reactive oxygen species (ROS), and participates in numerous physiological and ...
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Article
Open AccessMesenchymal stem cells overexpressing hepatocyte nuclear factor-4 alpha alleviate liver injury by modulating anti-inflammatory functions in mice
Mesenchymal stem cells (MSCs) can migrate to tissue injury sites where they can induce multipotential differentiation and anti-inflammation effects to treat tissue injury. When traditional therapeutic methods ...
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Article
Open AccessSleeve gastrectomy attenuates high fat diet-induced non-alcoholic fatty liver disease
A high-fat diet (HFD) is known to lead to obesity, and contributes to the progression of non-alcoholic fatty liver disease. The objective of this study was to evaluate the effects of sleeve gastrectomy (SG) on...
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Article
The Anatomy of Lateral Ligament of the Rectum and Its Role in Total Mesorectal Excision: Reply
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Article
Anorectal Functional Results After Transanal Endoscopic Microsurgery in Benign and Early Malignant Tumors
Transanal endoscopic microsurgery (TEM) has been suggested as a minimally invasive procedure of low morbidity for rectal villous adenomas and early anorectal adenocarcinomas. It has been used clinically in man...
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Article
The Anatomy of Lateral Ligament of the Rectum and Its Role in Total Mesorectal Excision
Lateral ligament of the rectum has suffered many diverse descriptions in its existence and composition. This study was undertaken to define the anatomy, nature, content of the lateral ligament of the rectum, a...
