122 Result(s)
within
Yuhao **ng
Life Sciences
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Article
Open AccessSETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
Transposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of transposable elements, are known to harbor...
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LbCOPT1 is a copper transporter induced in Lycium barbarum mycorrhizal roots, which allows tobacco with improved growth and nutrient uptake
Overexpressing the copper transporter LbCOPT1 leads to a notable increase in the abundance of mycorrhizal arbuscules that suggests the potential application of LbCOPT1 in breeding programs aimed at enhancing s...
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Ethylene may be the Key Factor Leading to the Homologous Transformation of Stamens into Pistils in Three-Pistil Wheat
Previous studies have shown that ethylene levels in flower buds are key to sex determination in plants. However, the roles of ethylene in wheat flower development are poorly understood. In this study, pistillo...
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Open AccessSystematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition
The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...
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Design, bioactivity and mechanism of N′-phenyl pyridylcarbohydrazides with broad-spectrum antifungal activity
Succinate dehydrogenase inhibitors (SDHIs) as one of the fastest-growing fungicide categories for plant protection. In this study, a series of N′-phenyl pyridylcarbohydrazides as analogues of commercial SDHIs wer...
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Open AccessFoldPAthreader: predicting protein folding pathway using a novel folding force field model derived from known protein universe
Protein folding has become a tractable problem with the significant advances in deep learning-driven protein structure prediction. Here we propose FoldPAthreader, a protein folding pathway prediction method th...
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Open AccessThe performance of microbial fuel cell with sodium alginate and super activated carbon composite gel modified anode
Microbial fuel cells (MFCs) have the functions of wastewater treatment and power generation. The incorporation of modified anodes enhances the sustainable power generation performance of MFCs. In this study, t...
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Effects of Testosterone in Mediating the Relationship Between Daytime Nap** and Osteoporosis in European Populations: A Mendelian Randomization Study
We aimed to explore the causal effect of daytime nap** on the risk of osteoporosis and the mediation role of testosterone in explaining this relationship. Summary data for Mendelian randomization (MR) analys...
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Open AccessIdentification and validation of biomarkers related to lipid metabolism in osteoarthritis based on machine learning algorithms
Osteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown.
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Open AccessA single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells
The occurrence of many autoimmune diseases takes root on the disrupted balance among Treg cells, Teff cells, etc. Low-dose interleukin-2 (IL-2) cytokine demonstrates promising clinical efficacy in the expansio...
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Open AccessGenomic investigation of duplication, functional conservation, and divergence in the LRR-RLK Family of Saccharum
Sugarcane (Saccharum spp.) holds exceptional global significance as a vital crop, serving as a primary source of sucrose, bioenergy, and various by-products. The optimization of sugarcane breeding by fine-tuning ...
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Open AccessSphingobium sp. V4, a bacterium degrading multiple allelochemical phenolic acids
Continuous crop** challenges constrain the development of agriculture. Three main obstacles limit continuous crop**: autotoxicity of plant allelochemicals, deterioration of physicochemical characteristics ...
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Open AccessCombined transcriptome and metabolome analysis reveals breed-specific regulatory mechanisms in Dorper and Tan sheep
Dorper and Tan sheep are renowned for their rapid growth and exceptional meat quality, respectively. Previous research has provided evidence of the impact of gut microbiota on breed characteristics. The precis...
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Synergistic effect of extra potassium application and AM fungi on drought tolerance of Lycium barbarum
Drought stress, one of the major abiotic stresses, affects plants growth by changing root morphology, impacting leaf water status and photosynthesis, and interrupting the reactive oxygen species (ROS) balance ...
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Open AccessFerroptosis in cardiovascular diseases: role and mechanism
In multicellular organisms, regulatory cell death is a crucial aspect of growth and development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell death that differs from apoptosis, au...
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Open AccessALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape
Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especia...
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Exosomal miR-218 derived from mesenchymal stem cells inhibits endothelial-to-mesenchymal transition by epigenetically modulating of BMP2 in pulmonary fibrosis
Endothelial-to-mesenchymal transition (EndMT), the process by which endothelial cells lose their characteristics and acquire mesenchymal phenotypes, participates in the pathogenic mechanism of idiopathic pulmo...
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Study on the four-point bending beam method to improve the testing accuracy for the elastic constants of wood
Using the static analysis of ANSYS 19, longitudinal, radial, and tangential beam specimens of spruce, Scots pine, and beech were subjected to stress and strain analysis under symmetrical four-point bending and...
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Open AccessMulti-domain and complex protein structure prediction using inter-domain interactions from deep learning
Accurately capturing domain-domain interactions is key to understanding protein function and designing structure-based drugs. Although AlphaFold2 has made a breakthrough on single domain, it should be noted th...
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Open AccessStructural characteristics of microbial exopolysaccharides in association with their biological activities: a review
Many microbial exopolysaccharides (EPS) have been reported in the last decade, and their fermentation processes, functional properties and applications, structural characterization, and biological activities h...
