-
Article
Open AccessSETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells
Transposable elements play a critical role in maintaining genome architecture during neurodevelopment. Short Interspersed Nuclear Elements (SINEs), a major subtype of transposable elements, are known to harbor...
-
Article
Open AccessTranscriptomic profiling of the develo** brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress
Prenatal stress (PS) is considered as a risk factor for many mental disorders. PS-induced transcriptomic alterations may contribute to the functional dysregulation during brain development. Here, we used RNA-s...
-
Article
Open AccessNeuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions
Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cereb...
-
Article
Open AccessEpigenetic mechanism of SETDB1 in brain: implications for neuropsychiatric disorders
Neuropsychiatric disorders are a collective of cerebral conditions with a multifactorial and polygenetic etiology. Dysregulation of epigenetic profiles in the brain is considered to play a critical role in the...
-
Article
Investigating the influential factors in the metro choice behavior: Evidences from Bei**g, China
In recent years, increasing concerns over climate change, and transportation energy consumption have sparked research into the travel behavior, especially metro use. The aim of this research is to investigate ...
