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Article
Open AccessEriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
Alzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural flavonoid compound that is mainly present in ...
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Article
Open AccessCooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity
Neuroplasticity refers to the changes in the molecular and cellular processes of neural circuits that occur in response to environmental experiences. Clinical and experimental studies have increasingly shown t...
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Article
Estrogen Modulates ubc9 Expression and Synaptic Redistribution in the Brain of APP/PS1 Mice and Cortical Neurons
Estrogen exerts multiple actions in the brain and is an important neuroprotective factor in a number of neuronal disorders. However, the underlying mechanism remains unknown. Studies demonstrate that ubiquitin...
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Article
Open AccessChronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons
Nicotine is known to differentially regulate cortical interneuron and pyramidal neuron activities in the neocortex, while the underlying molecular mechanisms have not been well studied. In this study, RNA-sequ...
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Article
Regulation and the Mechanism of Estrogen on Cav1.2 Gene in Rat-Cultured Cortical Astrocytes
L-type calcium channel (LTCC) gene Cav1.2 is believed to play an important role in the alteration of Ca2+ homeostasis in brain astrocytes. Increasing evidence shows that alteration of intracellular Ca2+ concentra...
