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Article
Short-term regulation of TSFM level does not alter amyloidogenesis and mitochondrial function in type-specific cells
Mitochondrial Ts translation elongation factor (TSFM) is an enzyme that catalyzes exchange of guanine nucleotides. By forming a complex with mitochondrial Tu translation elongation factor (TUFM), TSFM particip...
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Article
Simulation of gas–solid flow in sinter vertical cooling furnace
The velocity distribution of sinter and gas in vertical cooling furnace (VCF) has an important influence on gas–solid heat transfer. Based on the slot model of single hopper in the VCF of Meishan Iron and Stee...
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Article
Open AccessIGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...
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Article
Age- and Nicotine-Associated Gene Expression Changes in the Hippocampus of APP/PS1 Mice
The etiology of Alzheimer’s disease (AD) has been intensively studied. However, little is known about the molecular alterations in early-stage and late-stage AD. Hence, we performed RNA sequencing and assessed...
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Article
Open AccessCooperation of Genomic and Rapid Nongenomic Actions of Estrogens in Synaptic Plasticity
Neuroplasticity refers to the changes in the molecular and cellular processes of neural circuits that occur in response to environmental experiences. Clinical and experimental studies have increasingly shown t...
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Article
Estrogen Modulates ubc9 Expression and Synaptic Redistribution in the Brain of APP/PS1 Mice and Cortical Neurons
Estrogen exerts multiple actions in the brain and is an important neuroprotective factor in a number of neuronal disorders. However, the underlying mechanism remains unknown. Studies demonstrate that ubiquitin...
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Article
Open AccessChronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons
Nicotine is known to differentially regulate cortical interneuron and pyramidal neuron activities in the neocortex, while the underlying molecular mechanisms have not been well studied. In this study, RNA-sequ...
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Article
Open AccessCorrection: Corrigendum: Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex
Scientific Reports 5: Article number: 14099; published online: 15 September 2015; updated: 06 February 2017 The authors of Article made an error in preparation of the final version of Figure 2 and inadvertentl...
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Article
Regulation and the Mechanism of Estrogen on Cav1.2 Gene in Rat-Cultured Cortical Astrocytes
L-type calcium channel (LTCC) gene Cav1.2 is believed to play an important role in the alteration of Ca2+ homeostasis in brain astrocytes. Increasing evidence shows that alteration of intracellular Ca2+ concentra...
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Article
Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability
Abnormally synchronized synaptic transmission in the brain leads to epilepsy. Neuroligin-1 (NL1) is a synaptic cell adhesion molecule localized at excitatory synapses. NL1 modulates synaptic transmission and d...
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Article
Open AccessModulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex
Layer I neurons in the prefrontal cortex (PFC) exhibit extensive synaptic connections with deep layer neurons, implying their important role in the neural circuit. Study demonstrates that activation of nicotin...
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Article
Erratum to: Alzheimer disease and cancer risk: a meta-analysis
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Article
Alzheimer disease and cancer risk: a meta-analysis
Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are ...
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Article
Open AccessAβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex
Accumulation of β-amyloid (Aβ) and cholinergic deficiency are two prominent features of Alzheimer’s disease (AD). To understand how Aβ-induced dysfunction of the nicotinic system may contribute to cognitive im...
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Article
Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy
DNA methylation is a key epigenetic modification of DNA that is catalyzed by DNA methyltransferase (DNMT). Increasing evidence suggests that DNA methylation in neurons regulates synaptic plasticity as well as ...
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Protocol
Directional Restriction Site-Free Insertion of PCR Products into Vectors
The polymerase chain reaction (PCR) technique has proved to be a powerful tool for rapid amplification of DNA fragments of interest during cloning. Insertion of PCR products into suitable vectors in order to c...
