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Open AccessPharmacokinetic/pharmacodynamic evaluation of gamithromycin against rabbit pasteurellosis
Gamithromycin is an effective therapy for bovine and swine respiratory diseases but not utilized for rabbits. Given its potent activity against respiratory pathogens, we sought to determine the pharmacokinetic...
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Article
TRIM29 modulates proteins involved in PTEN/AKT/mTOR and JAK2/STAT3 signaling pathway and suppresses the progression of hepatocellular carcinoma
Tripartite motif–containing 29 (TRIM29), also known as the ataxia telangiectasia group D-complementing (ATDC) gene, has been reported to play an oncogenic or tumor suppressive role in develo** different tumo...
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Article
Open AccessTwo somatic mutations in the androgen receptor N-terminal domain are oncogenic drivers in hepatocellular carcinoma
The androgen receptor (AR) plays an important role in male-dominant hepatocellular carcinoma, and specific acquired somatic mutations of AR have been observed in HCC patients. Our previous research have establish...
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Article
Open AccessSEPT2 crotonylation promotes metastasis and recurrence in hepatocellular carcinoma and is associated with poor survival
Hepatocellular carcinoma (HCC) metastasis and recurrence lead to therapy failure, which are closely associated with the proteome. However, the role of post-translational modification (PTM) in HCC, especially f...
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Article
Open AccessConsistent explanation for the cosmic-ray positron excess in p-wave Breit–Wigner enhanced dark matter annihilation
Dark matter (DM) annihilation in the galactic halo can be enhanced relative to that in the early Universe due to the Breit–Wigner enhancement, if the DM particles annihilate through a narrow resonance. Althoug...
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Improved constraints on dark matter effective interactions from CDEX
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Open AccessCleaning the palate and tongue without nausea: a mixed methods study exploring the appropriate depth and direction of oral care
It is advisable to clean the palate and tongue thoroughly during oral care to protect against nosocomial infections. However, improper cleaning may cause nausea. To date, no robust data are available regarding...
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Article
Open AccessEnvironmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal c...
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Open AccessEpidemiological and PK/PD cutoff values determination and PK/PD-based dose assessment of gamithromycin against Haemophilus parasuis in piglets
Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus...
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Article
Open AccessA core effector UV_1261 promotes Ustilaginoidea virens infection via spatiotemporally suppressing plant defense
False smut is a destructive grain disease of rice worldwide, characterized by false smut balls formed in rice flowers. Here we identified a small secreted protein UV_1261 contributing to virulence of Ustilaginoid...
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Article
Open AccessPharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks
This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. coli O78 strain in Muscovy ducks. T...
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Open AccessIn vitro Dynamic Pharmacokinetic/Pharamcodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis
Haemophilus parasuis (H. parasuis) can invade the body and cause systemic infection under stress conditions. Marbofloxacin has been recommended for the treatment of swine infections. H...
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Open AccessIn vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis
Haemophilus parasuis (H. parasuis) causes Glässer’s disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed f...
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Article
Open AccessStrongly first order phase transition in the singlet fermionic dark matter model after LUX
We investigate an extension of the standard model (SM) with a singlet fermionic dark matter (DM) particle which interacts with the SM sector through a real singlet scalar. The presence of a new scalar provides...
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Enhancement of dark matter relic density from late time dark matter conversions
We demonstrate that if the dark matter (DM) in the Universe contains multiple components, the possible interactions between the DM components may convert the heavier DM components into lighter ones. It is then...
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Article
Mixing-induced CP violating sources for electroweak baryogenesis from a semiclassical approach
The effects of flavor mixing in electroweak baryogenesis is investigated in a generalized semiclassical WKB approach. Through calculating the non-adiabatic corrections to the particle currents, it is shown tha...
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Article
Study on dam** properties of magnetorheological damper
To research the properties of a new kind of smart controllable MR (magnetorheological) fluid, in this paper, the rheological models are discussed. On the basis of analyzing the structural forms of MR dampers, ...
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Article
Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/ Akt signaling pathways
To investigate the effects of Sonic hedgehog (shh) protein on bone marrow-derived endothelial progenitor cells (BM-EPC) proliferation, migration and vascular endothelial growth factor (VEGF) production, and th...
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Article
Determining weak phase γ and probing new physics in b→s transitions from B→η(’)K
We present a method of determining the weak phase γ in the Cabibbo–Kobayashi–Maskawa matrix from the decays B→ηK,η’K alone. Given a large ratio between color-suppressed and color-allowed tree diagrams extracte...
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Exploring final state hadron structure and SU(3) flavor symmetry breaking effects in \(D\to PP\) and \(D\to PV\) decays
The non-leptonic two body decays \(D\to PP\) and ...
