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  1. Article

    Open Access

    Prognostic and therapeutic implications of TP53 expression in chronic myelomonocytic leukemia

    Yu-Hung Wang, Chien-Chin Lin, Kristian Gurashi, Chi-Yuan Yao in Blood Cancer Journal (2024)

  2. Article

    Open Access

    Deep Learning–Based Localization and Detection of Malpositioned Nasogastric Tubes on Portable Supine Chest X-Rays in Intensive Care and Emergency Medicine: A Multi-center Retrospective Study

    Malposition of a nasogastric tube (NGT) can lead to severe complications. We aimed to develop a computer-aided detection (CAD) system to localize NGTs and detect NGT malposition on portable chest X-rays (CXRs)...

    Chih-Hung Wang, Tianyu Hwang, Yu-Sen Huang in Journal of Imaging Informatics in Medicine (2024)

  3. Article

    Open Access

    Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue

    Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry (IHC) is the golden standard in predicting immunotherapy response of non-small cell lung cancer (NSCLC). However, observation...

    Hsien-Neng Huang, Chun-Wei Kuo, Yu-Ling Hung, Chia-Hung Yang in Scientific Reports (2024)

  4. Article

    Open Access

    Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

    Esophagectomy after chemoradiotherapy is associated with an increased risk of surgical complications. The significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio after chem...

    Chien-Ming Lo, Hung-I. Lu, Yu-Ming Wang, Yen-Hao Chen, Yu Chen in Perioperative Medicine (2024)

  5. No Access

    Article

    Dynamic change of metabolic dysfunction-associated steatotic liver disease in patients with hepatitis C virus infection after achieving sustained virologic response with direct-acting antivirals

    Information on the dynamics of metabolic dysfunction-associated steatotic liver disease (MASLD) among hepatitis C virus patients achieving sustained virologic response (SVR12) with direct-acting antivirals (DAAs)...

    Chen-Hua Liu, Yu-** Chang, Yu-Jen Fang, Pin-Nan Cheng in Journal of Gastroenterology (2024)

  6. Article

    Open Access

    Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation

    3-Bromofluoranthene (3-BrFlu) is the secondary metabolite of fluoranthene, which is classified as a polycyclic aromatic hydrocarbon, through bromination and exists in the fine particulate matter of air polluta...

    Chien-Ying Lee, Sheng-Wen Wu, Jiann-Jou Yang, Wen-Ying Chen in Archives of Toxicology (2024)

  7. No Access

    Article

    Validation of the constitution in Chinese medicine questionnaires with the newly developed blood-vacuity category: a rare Taiwanese case study

    The concept of body constitution (BC) is a core notion in traditional Chinese medicine, used in diagnosis, treatment, and prevention; however, there is little standardization in terms of definitions and measur...

    Ting-Yu Huang, Shi-Chen Ou, Wei-Te Huang, Yu-Chuan Lin in Advances in Traditional Medicine (2024)

  8. No Access

    Article

    Three-Month Excessive Body Weight Loss < 37.7% as a Predictor of Mid-term Suboptimal Outcomes Postlaparoscopic Sleeve Gastrectomy: Risk Factors and the Impact of Neutrophil-to-Lymphocyte Ratio on Adipocyte Function

    This study aimed to evaluate the impact of achieving < 37.7% excess body-weight loss (EBWL) within 3 months of postlaparoscopic sleeve gastrectomy (LSG) on clinical outcomes and its correlation with adipocyte ...

    Jian-Han Chen, Po-Jui Chi, Chung-Yen Chen, Chi‑Ming Tai, Po-Jen Chen in Obesity Surgery (2024)

  9. Article

    Open Access

    Develo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity

    Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...

    Chung-Pei Fu, Ching-Kai Huang, Yi-Chiun Yang, Wei-Sheng Liao in BMC Medical Education (2024)

  10. Article

    Open Access

    Understanding and alleviating informal caregiver burden through the development and validation of a caregiver strain index-based model in Taiwan

    Quantifying the informal caregiver burden is important for understanding the risk factors associated with caregiver overload and for evaluating the effectiveness of services provided in Long-term Care (LTC).

    Shuo-Chen Chien, Yu-Hung Chang, Chia-Ming Yen, Ying-Erh Chen in BMC Geriatrics (2024)

  11. Article

    Open Access

    Transposase-assisted target-site integration for efficient plant genome engineering

    The current technologies to place new DNA into specific locations in plant genomes are low frequency and error-prone, and this inefficiency hampers genome-editing approaches to develop improved crops1,2. Often co...

    Peng Liu, Kaushik Panda, Seth A. Edwards, Ryan Swanson, Hochul Yi in Nature (2024)

  12. No Access

    Article

    Temporal Trends in Survival Outcomes for Patients with Esophageal Cancer Following Neoadjuvant Chemoradiotherapy: A 14-Year Analysis

    The prognosis for patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nCRT) followed by surgery has shown improvement in recent years. We sought to identify the critical factors contrib...

    Chong Beng Ng MD, Chien-Hung Chiu MD, Chi-Ju Yeh MD in Annals of Surgical Oncology (2024)

  13. Article

    Open Access

    Sex differences in the association of long-term exposure to heat stress on kidney function in a large Taiwanese population study

    The incidence and prevalence of dialysis in Taiwan are high compared to other regions. Consequently, mitigating chronic kidney disease (CKD) and the worsening of kidney function have emerged as critical health...

    Yi-Kong Chen, **-Hsun Wu, Pei-Yu Wu, Yi-Chun Tsai, Yi-Wen Chiu in Scientific Reports (2024)

  14. Article

    Open Access

    The risk of herpes zoster is positively associated with obesity, especially morbid obesity

    This study aimed to investigate the association between obesity and herpes zoster (HZ) occurrence. This study used data covering 2 million people in Taiwan in 2000, which were obtained from the National Health...

    Hsiao-Lan Chen, Chia-Hung Chen, Wen-Che Hsieh, Yu-Han Huang in Scientific Reports (2024)

  15. No Access

    Article

    Differentiation in theta and gamma activation in weight-shifting learning between people with parkinson’s disease of different anxiety severities

    Anxiety and postural control deficits may be related in people with Parkinson’s disease (PwPD). However, the association between anxiety levels and weight-shifting control remains ambiguous. This study investi...

    Yu-Ting Hung, Ruey-Meei Wu, Cheng-Ya Huang in GeroScience (2024)

  16. No Access

    Article

    Accounting conservatism, corporate diversification and firm value

    This study investigates the impact of conservative financial reporting on corporate diversification, in order to explore whether accounting policy plays a role in mitigating agency problems associated with cor...

    Chloe Yu-Hsuan Wu, Shou-Min Tsao in Review of Quantitative Finance and Account… (2024)

  17. Article

    Open Access

    Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth

    Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecul...

    I-Hsuan Lin, Yue-Ru Li, Chia-Hsiang Chang, Yu-Wen Cheng in Cell Death & Differentiation (2024)

  18. Article

    Open Access

    SpliceAPP: an interactive web server to predict splicing errors arising from human mutations

    Splicing variants are a major class of pathogenic mutations, with their severity equivalent to nonsense mutations. However, redundant and degenerate splicing signals hinder functional assessments of sequence v...

    Ang-Chu Huang, Jia-Ying Su, Yu-Jen Hung, Hung-Lun Chiang, Yi-Ting Chen in BMC Genomics (2024)

  19. Article

    Open Access

    Examining customer intentions to purchase intelligent robotic products and services in Taiwan using the theory of planned behaviour

    The literature for assessing online and offline shop** behaviours that are linked to intelligent robotic goods and services is inadequate. In this study, we applied the Theory of Planned Behaviour model for ...

    Yu-Hung Tai, Precious Toby T. Nwachukwu, Ben A. LePage, Wei-Ta Fang in BMC Psychology (2024)

  20. Article

    Open Access

    Effectiveness of fentanyl buccal soluble film in cancer patients with inadequate breakthrough pain control

    Clinical evidence for the rapidity and effectiveness of fentanyl buccal soluble film (FBSF) in reducing pain intensity of breakthrough cancer pain (BTcP) remains inadequate. This study aimed to evaluate the ef...

    Yi-Hao Chiang, Ching-Ting Lien, Wen-Hao Su, Tsung-Yu Yen in BMC Palliative Care (2024)

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