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Open AccessTransposase-assisted target-site integration for efficient plant genome engineering
The current technologies to place new DNA into specific locations in plant genomes are low frequency and error-prone, and this inefficiency hampers genome-editing approaches to develop improved crops1,2. Often co...
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Reading banned regions of genomes
The effect of DNA methylation on gene expression has been known for decades. However, the mechanism by which DNA methylation functions to repress transcription has remained a major question in the field. Wang ...
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Open AccessThe networked micro-decision context: a new lens on transformative urban governance
Recent large-scale societal disruptions, from the COVID-19 pandemic to intensifying wildfires and weather events, reveal the importance of transforming governance systems so they can address complex, transboun...
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Open AccessThe engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In so...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
