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Chapter
Design of Social Isolation Index
Social indicators are statistics that allow us to understand the current situation and changes in the social system to implement appropriate interventions. Current social indicators have a problem of lack of m...
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Article
Open AccessGlycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
The most frequent genetic cause of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the expansion of a GGGGCC hexanucleotide repeat in a non-coding region of the chromosome 9...
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Article
Open AccessBinding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
Amyloid-β peptide ending at 42nd residue (Aβ42) is believed as a pathogenic peptide for Alzheimer disease. Although γ-secretase is a responsible protease to generate Aβ through a processive cleavage, the prote...
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Article
Open AccessExperimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana
Signal peptide peptidase (SPP) is a multi-transmembrane aspartic protease involved in intramembrane-regulated proteolysis (RIP). RIP proteases mediate various key life events by releasing bioactive peptides fr...
