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Article
A homeostatic role of nucleus-actin filament coupling in the regulation of cellular traction forces in fibroblasts
Cellular traction forces are contractile forces that depend on the material/substrate stiffness and play essential roles in sensing mechanical environments and regulating cell morphology and function. Traction...
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Article
Open AccessResilient anatomy and local plasticity of naive and stress haematopoiesis
The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize...
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Article
Open AccessAnti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid env...
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Article
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment
Uncontrolled inflammatory response arising from the tumor microenvironment (TME) significantly contributes to cancer progression, prompting an investigation and careful evaluation of counter-regulatory mechani...
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Chapter and Conference Paper
Effect of Electrode Length and Gas Velocity on the Collection of Diesel Exhaust Particle in an Electrostatic Precipitator with a High Electric Field
In this study, the effect of the electrode length and the gas velocity on the collection of diesel exhaust particle (DEP) in an electrostatic precipitator (ESP) with a high electric field, which does not use c...
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Protocol
High Cell-Density Expression System: Yeast Cells in a Phalanx Efficiently Produce a Certain Range of “Difficult-to-Express” Secretory Recombinant Proteins
Yeast’s extracellular expression provides a cost-efficient means of producing recombinant proteins of academic or commercial interests. However, depending on the protein to be expressed, the production occasio...
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Article
Open AccessImpending Blindness by Obstructive Hydrocephalus Intractable to Endoscopic Third Ventriculostomy: Case Report
Endoscopic third ventriculostomy (ETV) has been accepted for obstructive hydrocephalus (OH). We herein present a case of OH and optic nerve sheath edema (ONSE). Although ETV was successful, ONSE worsened. Disc...
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Article
Primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation: a similar cytological appearance as its soft tissue counterpart but no lobulation in association with desmoplastic stroma
The CIC-DUX4 translocation is the most common genetic alteration of small round cell sarcomas without EWSR1 rearrangement. These “Ewing-like sarcomas” usually occur in peripheral soft tissues, and rare primary ce...
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Article
Open AccessA conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Land plants produce diverse flavonoids for growth, survival, and reproduction. Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2′,4,4′,6′-t...
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Article
Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2′-O-methylation (...
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Article
The association between sacroiliac joint-related pain following lumbar spine surgery and spinopelvic parameters: a prospective multicenter study
To prospectively calculate the incidence of postoperative sacroiliac joint-related pain (SIJP) and investigate the association between spinopelvic parameters and postoperative SIJP after lumbar spine surgery.
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Article
Metabolism as master of hematopoietic stem cell fate
HSCs have a fate choice when they divide; they can self-renew, producing new HSCs, or produce daughter cells that will mature to become committed cells. Technical challenges, however, have long obscured the me...
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Article
Open AccessIdentification of soybean peptide leginsulin variants in different cultivars and their insulin-like activities
We have recently reported that green soybean cultivar, echigomidori, and not the yellow cultivar, fukuyutaka, is a rich source of hormone-like peptide leginsulin consisting of 37 amino acids (Leg_1_37, PDB 1JU8A)...
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Article
Open AccessA non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance o...
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Article
Open AccessImage-guided transplantation of single cells in the bone marrow of live animals
Transplantation of a single hematopoietic stem cell is an important method for its functional characterization, but the standard transplantation protocol relies on cell homing to the bone marrow after intraven...
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Article
Open AccessMPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells
Regulation of cell death is potentially a powerful treatment modality for intractable diseases such as neurodegenerative diseases. Although there have been many reports about the possible involvement of variou...
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Article
Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma
Glioma stem cells (GSCs) have the capacity to repopulate tumors and mediate resistance to radiotherapy and chemotherapy. The Notch signaling pathway is important in proliferation, stem cell maintenance, cell d...
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Article
Mitochondrial control of hematopoietic stem cell balance and hematopoiesis
Hematopoietic stem cells (HSCs) are stem cells from mesodermal derivation that reside in bone marrow and provide blood cells for the whole life of an adult individual, through a process called hematopoiesis. T...
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Protocol
High Cell-Density Expression System: Yeast Cells in a Phalanx Efficiently Produce a Certain Range of “Difficult-to-Express” Secretory Recombinant Proteins
Yeast’s extracellular expression provides a cost-efficient means of producing recombinant proteins of academic or commercial interests. However, depending on the protein to be expressed, the production occasio...
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Article
Inter-specific and sexual differences in architectural traits of two dioecious Lindera species (Lauraceae)
The architecture of trees is a crucial determinant of their performance through light capture and mechanical stability. Comparison of architectural traits between closely related dioecious species is predicted...
