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  1. No Access

    Article

    Identification of four metabolites of 3-(phenylamino)alanine, a constituent in l-tryptophan products implicated in eosinophiliamyalgia syndrome, in rats

    3-(Phenylamino)alanine (PAA), a contaminant found in l-tryptophan tablets, has been discussed as a possible cause of eosinophilia-myalgia syndrome (EMS). We administered PAA (100 mg/kg) by gastric gavage to Wista...

    Junko Adachi, Takaya Mio, Yasuhiro Ueno, Takeaki Naito… in Archives of Toxicology (1994)

  2. No Access

    Article

    Accumulation of 1-methyl-tetrahydro-Β-carboline-3-carboxylic acid in blood and organs of rat. A possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan

    1-Methyl-tetrahydro-Β-carboline-3-carboxylic acid (MTCA) may cause eosinophilia-myalgia syndrome (EMS) associated with ingestion ofl-tryptophan. The distribution and excretion of MTCA were studied in rats which h...

    Yumi Ogawa, Junko Adachi, Yoshitsugu Tatsuno in Archives of Toxicology (1993)

  3. No Access

    Article

    Metabolism and distribution in the rat of peak E substance, a constituent inl-tryptophan product implicated in eosinophilia-myalgia syndrome

    Peak E substance, 1,1′-ethylidenebis[tryptophan], a contaminant found inl-tryptophan tablets, has been suggested as a causative agent for eosinophilia-myalgia syndrome (EMS). Peak E substance (50 mg/kg) was admin...

    Junko Adachi, Takeaki Naito, Yasuhiro Ueno, Yumi Ogawa… in Archives of Toxicology (1993)

  4. No Access

    Article

    Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan

    1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (MTCA) is now thought to be a possible causative substance of eosinophilia-myalgia syndrome associated with ingestion ofl-tryptophan. In the present study...

    Junko Adachi, Kenji Yamamoto, Yumi Ogawa, Yasuhiro Ueno… in Archives of Toxicology (1991)