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    Article

    Novel role of PKR in inflammasome activation and HMGB1 release

    Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility gr...

    Ben Lu, Takahisa Nakamura, Karen Inouye, Jianhua Li, Yiting Tang, Peter Lundbäck in Nature (2012)

  2. Article

    Open Access

    Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development

    Type I diabetes (TID) is an autoimmune disease resulting from destruction of the insulin-producing β-cells by autoreactive T cells. Studies have shown that polymorphisms of chemokine CXCL12 gene are linked to ...

    Qibin Leng, Yuchun Nie, Yongrui Zou, Jianzhu Chen in BMC Immunology (2008)