16 Result(s)

Article

Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors

Reinvigoration of antitumor immunity has recently become the central theme for the development of cancer therapies. Nevertheless, the precise delivery of immunotherapeutic activities to the tumors remains chal...

Yafeng Wang, Guiquan Zhang, Qingzhou Meng, Shisheng Huang… in Nature Communications (2022)

Article

Interleukin-8 as a candidate for thymoma identification and recurrence surveillance

Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnor...

Shilin Gao, Jiahao Jiang, Chun **, Jian Gao, Dian **ong… in Nature Communications (2020)

Article

ProGeo-neo: a customized proteogenomic workflow for neoantigen prediction and selection

Neoantigens can be differentially recognized by T cell receptor (TCR) as these sequences are derived from mutant proteins and are unique to the tumor. The discovery of neoantigens is the first key step for tum...

Yuyu Li, Guangzhi Wang, **aoxiu Tan, Jian Ouyang, Menghuan Zhang… in BMC Medical Genomics (2020)

Article

PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1

Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury or even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisp...

Lin Wang, Yilong Zhou, Zijuan Chen, Lei Sun, Juehui Wu, Haohao Li… in Nature Communications (2019)

Article

Antiviral effects of ferric ammonium citrate

Iron is an essential nutrient for cell survival and is crucial for DNA replication, mitochondrial function and erythropoiesis. However, the immunological role of iron in viral infections has not been well defi...

Hongbin Wang, Zheng Li, Junling Niu, Yongfen Xu, Li Ma, Ailing Lu… in Cell Discovery (2018)

Article

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self ...

Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang… in Nature Communications (2017)

Article

Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8⁺ T cell responses during acute Friend retrovirus infection

Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model,...

Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng… in Retrovirology (2017)

Article

USP21 prevents the generation of T-helper-1-like Treg cells

FOXP3⁺ Regulatory T (Treg) cells play a key role in the maintenance of immune homeostasis and tolerance. Disruption of Foxp3 expression results in the generation of instable Treg cells and acquisition of effector...

Yangyang Li, Yue Lu, Shuaiwei Wang, Zhijun Han, Fuxiang Zhu… in Nature Communications (2016)

Article

Non-classical MHC I-E negatively regulates macrophage activation and Th17 cell development in NOD mice

Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E^k alpha 16 ...

Chunhui Yang, Nining Guo, **hua Liu, Juhao Yang, Kai Zhu, Hui **ao… in Scientific Reports (2015)

Article

Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome

Guowei Lei, Mingkuan Chen, Hua Li, Jun-Ling Niu, Shuxian Wu, Liming Mao… in Cell Research (2013)

Article

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

NOD-like receptors (NLRs) are a family of intracellular proteins that play critical roles in innate immunity against microbial infection. NLRC5, the largest member of the NLR family, has recently attracted muc...

Yikun Yao, Yalong Wang, Fuxiang Chen, Yin Huang, Shu Zhu, Qibin Leng… in Cell Research (2012)

Article

Construction and characterization of an infectious clone of coxsackievirus A16

Coxsackievirus A16 (CVA16) is a member of the Enterovirus genus of the Picornaviridae family and it is a major etiological agent of hand, foot, and mouth disease (HFMD), which is a common illness affecting childr...

Fei Liu, Qingwei Liu, Yicun Cai, Qibin Leng, Zhong Huang in Virology Journal (2011)

Article

Neutralizing antibody response in the patients with hand, foot and mouth disease to enterovirus 71 and its clinical implications

Enterovirus 71 (EV71) has emerged as a significant pathogen causing large outbreaks in China for the past 3 years. Develo** an EV71 vaccine is urgently needed to stop the spread of the disease; however, the ...

Chunfu Yang, Chaoyang Deng, Junfeng Wan, Liye Zhu, Qibin Leng in Virology Journal (2011)

Article

Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development

Type I diabetes (TID) is an autoimmune disease resulting from destruction of the insulin-producing β-cells by autoreactive T cells. Studies have shown that polymorphisms of chemokine CXCL12 gene are linked to ...

Qibin Leng, Yuchun Nie, Yongrui Zou, Jianzhu Chen in BMC Immunology (2008)