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  1. No Access

    Article

    Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain

    RNA interference (RNAi) for spinocerebellar ataxia type 1 can prevent and reverse behavioral deficits and neuropathological readouts in mouse models, with safety and benefit lasting over many months. The RNAi ...

    Megan S. Keiser, Paul T. Ranum, Carolyn M. Yrigollen, Ellie M. Carrell… in Nature Medicine (2021)

  2. No Access

    Article

    Prediction of intravenous immunoglobulin resistance in Kawasaki disease in children

    We aimed to explore predictive measures for intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD).

    Shu Wu, Ying Liao, Yan Sun, Chun-Yu Zhang, Qing-You Zhang… in World Journal of Pediatrics (2020)

  3. No Access

    Article

    Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity

    Upregulation of sodium channel SCN3A expression in epileptic tissues is known to contribute to enhancing neuronal excitability and the development of epilepsy. Therefore, certain strategies to reduce SCN3A expres...

    Na-Na Tan, Hui-Ling Tang, Guo-Wang Lin, Yong-Hong Chen, ** Lu… in Molecular Neurobiology (2017)

  4. No Access

    Article

    Synthesis and Fluorescent Properties of a Chiral 2D Tetranuclear Cd(II) Coordination Polymer Based on Asymmetrical Biphenyltetracarboxylate

    Solvothermal reaction of Cd(OAc)2·2H2O and biphenyl-2,3,3′,5′-tetracarboxylic acid (H4bptca) in DMF/H2O afforded one novel coordination polymer [Cd4(bptca)2(DMF)4]n (1). X-ray structural analysis reveals that com...

    Gui-Lin Wen, Ming-Rong Hua, **ao-Ling Wang… in Journal of Inorganic and Organometallic Po… (2016)

  5. No Access

    Article

    Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

    The brain vasculature forms an immense network such that most neural cells are in contact with a microvessel. Here we tested the hypothesis that endothelia lining these vessels can be harnessed to create a cel...

    Yong Hong Chen, Michael Chang, Beverly L Davidson in Nature Medicine (2009)

  6. No Access

    Article

    LC Analysis of Aliphatic Primary Amines and Diamines After Derivatization with 2,6-Dimethyl-4-quinolinecarboxylic Acid N-Hydroxysuccinimide Ester

    A method for sensitive simultaneous analysis of aliphatic primary amines and diamines has been developed and validated. The compounds were analyzed by reversed-phase high-performance liquid chromatography afte...

    Ke-**g Huang, Cai-Yun Wei, Wan-Zhen **e, Yan-Ming Liu, Yong-Hong Chen… in Chromatographia (2009)

  7. No Access

    Article

    Isotope edited product ion assignment by α-N labeling of peptides with [2H3(50%)]2,4-Dinitrofluorobenzene

    An isotopic modification of Sanger’s method for identifying peptide N-termini has been developed to assist peptide sequencing by tandem mass spectrometry. Tryptic peptides, such as Val-His-Leu-Thr-Pro-Val-Glu-...

    **aohui Chen, Vernon E. Anderson… in Journal of the American Society for Mass S… (1999)