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  1. Article

    Open Access

    HLA class I genes modulate disease risk and age at onset together with DR-DQ in Chinese patients with insulin-requiring type 1 diabetes

    The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes.

    Ziyu Jiang, Wenqian Ren, Hua Liang, **hua Yan, Daizhi Yang, Sihui Luo… in Diabetologia (2021)

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  2. Article

    Open Access

    Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

    The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs...

    Yang Liu, Shuai He, **-Liang Wang, Wan Peng, Qiu-Yan Chen… in Nature Communications (2021)

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  3. Article

    Open Access

    Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs

    As core units of organ tissues, cells of various types play their harmonious rhythms to maintain the homeostasis of the human body. It is essential to identify the characteristics of cells in human organs and ...

    Shuai He, Lin-He Wang, Yang Liu, Yi-Qi Li, Hai-Tian Chen, **g-Hong Xu… in Genome Biology (2020)

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  4. No Access

    Article

    Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity

    Upregulation of sodium channel SCN3A expression in epileptic tissues is known to contribute to enhancing neuronal excitability and the development of epilepsy. Therefore, certain strategies to reduce SCN3A expres...

    Na-Na Tan, Hui-Ling Tang, Guo-Wang Lin, Yong-Hong Chen, ** Lu… in Molecular Neurobiology (2017)